Uses
ChemicalBook > CAS DataBase List > 3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE

3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE

Uses
Product Name
3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE
CAS No.
88444-81-9
Chemical Name
3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE
Synonyms
1-ETHYNYL-3;SALOR-INT L308668-1EA;3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE;1-ETHYNYL-3,5-BIS(TRIFLUOROMETHYL)BENZE&;1-ETHYNYL-3,5-BIS(TRIFLUOROMETHYL)BENZENE;3,5-BIS(TRIFLUOROMETHYL)-1-ETHYNYLBENZENE;3',5'-BIS-TRIFLUOROMETHYLPHENYL ACETYLENE;1,3-Bis(trifluoromethyl)-5-ethynylbenzene;3',5'-Bis(trifluoromethyl)phenylacetylene;Benzene, 1-ethynyl-3,5-bis(trifluoroMethyl
CBNumber
CB1724938
Molecular Formula
C10H4F6
Formula Weight
238.13
MOL File
88444-81-9.mol
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3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE Property

Boiling point:
147-148 °C (lit.)
Density 
1.346 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4230(lit.)
Flash point:
112 °F
storage temp. 
2-8°C
form 
clear liquid
color 
Colorless to Light yellow to Light orange
InChI
InChI=1S/C10H4F6/c1-2-6-3-7(9(11,12)13)5-8(4-6)10(14,15)16/h1,3-5H
InChIKey
MAHIBRPXUPUAIF-UHFFFAOYSA-N
SMILES
C1(C#C)=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
CAS DataBase Reference
88444-81-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
10-36/37/38
Safety Statements 
16-26-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
3
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
630241
Product name
1-Ethynyl-3,5-bis(trifluoromethyl)benzene
Purity
97%
Packaging
1g
Price
$61.62
Updated
2025/07/31
TCI Chemical
Product number
E1353
Product name
1-Ethynyl-3,5-bis(trifluoromethyl)benzene
Purity
>98.0%(GC)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
E1353
Product name
1-Ethynyl-3,5-bis(trifluoromethyl)benzene
Purity
>98.0%(GC)
Packaging
5g
Price
$141
Updated
2025/07/31
TRC
Product number
T790958
Product name
3,5-Bis(Trifluoromethyl)phenylacetylene
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
T790958
Product name
3,5-Bis(Trifluoromethyl)phenylacetylene
Packaging
100mg
Price
$60
Updated
2021/12/16
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3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE Chemical Properties,Usage,Production

Uses

3,5-Bis(trifluoromethyl)phenylacetylene is a useful research chemical.

Chemical Properties

Yellow liquid

Synthesis

618092-28-7

88444-81-9

General procedure for the synthesis of 3,5-bis(trifluoromethyl)phenylethynyltrimethylsilane from (3,5-bis(trifluoromethyl)phenylethynyl)trimethylsilane: To a mixed solution of 2-[3,5-bis(trifluoromethyl)phenyl]ethynyltrimethylsilane (83.1g, 267.7mmol) in methanol (70mL) and chloroform (70mL) was added potassium carbonate (7.4g, 53.5 mmol), followed by stirring the reaction mixture at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue and extracted with ether. The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure to give the crude product. The crude product was further purified by reduced pressure distillation (82 °C, 100 mbar) to afford 3,5-bis(trifluoromethyl)phenylacetylene (48.7 g, 76% yield) as a colorless oil. The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.92 (2H, s), 7.84 (1H, s), 3.26 (1H, s).

References

[1] Dalton Transactions, 2012, vol. 41, # 3, p. 839 - 849
[2] Patent: US2018/290986, 2018, A1. Location in patent: Paragraph 0230; 0231
[3] Journal of Organic Chemistry, 1993, vol. 58, # 24, p. 6614 - 6619
[4] Chemical Communications, 2008, # 19, p. 2203 - 2205
[5] Journal of Materials Chemistry C, 2017, vol. 5, # 31, p. 7977 - 7984

3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE Suppliers

Americas 1 China 78 Europe 1 Germany 3 India 2 Italy 1 Japan 1 Switzerland 1 United Kingdom 8 United States 19 Global 115
Alchem Pharmtech,Inc.
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View Lastest Price from 3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE manufacturers

Henan Fengda Chemical Co., Ltd
Product
3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE 88444-81-9
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Ethynyl-3,5-bis(trifluoromethyl)benzene 88444-81-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

88444-81-9, 3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENERelated Search:

4'-TRIFLUOROMETHYLPHENYL ACETYLENE Phenylacetylene 3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE 2,5-bis(trifluoromethyl)phenylacetylene (3,5-BIS(TRIFLUOROMETHYL)PHENYLETHYNYL)& BIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ACETYLENE 3,5-BIS(TRIFLUOROMETHYL)DIPHENYLACETYLENE FLUPROPADINE (3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]PROP-2-YNYL)(TRIETHYL)AMMONIUM BROMIDE N-(3-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-1,1-DIMETHYLPROP-2-YNYL)-2-CHLOROACETAMIDE 3-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROP-2-YN-1-OL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]PROP-2-YNYL N-(1,2,2-TRICHLOROVINYL)CARBAMATE 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-3-BUTYN-2-OL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]PROP-2-YNYL 2-CHLOROACETATE 1-(3-BROMOPROP-1-YNYL)-3,5-DI(TRIFLUOROMETHYL)BENZENE 1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-HYDROXY-3-METHYL-1-BUTYNE

  • 3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE
  • 3',5'-BIS-TRIFLUOROMETHYLPHENYL ACETYLENE
  • 3,5-BIS(TRIFLUOROMETHYL)-1-ETHYNYLBENZENE
  • 1-ETHYNYL-3,5-BIS(TRIFLUOROMETHYL)BENZENE
  • SALOR-INT L308668-1EA
  • 1-ETHYNYL-3,5-BIS(TRIFLUOROMETHYL)BENZE&
  • 3,5-Bis(trifluoromethyl)phenylacetylene 99+%
  • Benzene, 1-ethynyl-3,5-bis(trifluoroMethyl
  • 1,3-Bis(trifluoromethyl)-5-ethynylbenzene
  • 1-Ethynyl-3,5-bis(trifluoroMethyl)benzene 97%
  • 1-ETHYNYL-3
  • 3,5-Bis(trifluoromethyl)phenylacetylene 99%
  • 3,5-BIS(TRIFLUOROMETHYL)PHENYLACETYLENE ISO 9001：2015 REACH
  • 3',5'-Bis(trifluoromethyl)phenylacetylene
  • 88444-81-9
  • CH8801CC6H3CF32
  • C10H4F6
  • C10H3F6
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