L-ASPARTIC ACID (3-13C)

L-ASPARTIC ACID (3-13C) Property

Melting point:

>300 °C (dec.)(lit.)

optical activity

[α]25/D +25.0°, c =2 in 5 M HCl

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1/i1+1

InChIKey

CKLJMWTZIZZHCS-IJGDANSWSA-N

SMILES

N[C@@H]([13CH2]C(O)=O)C(O)=O

CAS Number Unlabeled

56-84-8

Safety

Safety Statements 

22-24/25

WGK Germany 

WGK 2

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

L-ASPARTIC ACID (3-13C) Chemical Properties,Usage,Production

Uses

L-Aspartic acid-13C-1 is the deuterium labeled L-Aspartic acid[1]. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[2][3].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. DOI:10.1046/j.1471-4159.1999.0731206.x
[3] Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug23(4):397-406. DOI:10.1007/BF02353640