IMIPRAMINE

Product Name: IMIPRAMINE
CAS No.: 50-49-7
Chemical Name: IMIPRAMINE
Synonyms: IM;DPID;Irmin;Iramil;Imizin;Imiprin;Imizine;Surplix;Timolet;Censtim
CBNumber: CB1727489
Molecular Formula: C19H24N2
Formula Weight: 280.41
MOL File: 50-49-7.mol

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IMIPRAMINE Property

Melting point:: 174°C
Boiling point:: bp0.1 160°
Density: 0.9935 (rough estimate)
refractive index: 1.5640 (estimate)
pka: pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
form: Liquid
color: Colorless to light yellow
Water Solubility: 18.23mg/L(24 ºC)
Solvent: Ethanol under nitrogen
Concentration: 1 mCi/ml
Specific Activity: 60-90 Ci/mmol
BCS Class: 1
EPA Substance Registry System: Imipramine (50-49-7)

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Safety

Hazardous Substances Data: 50-49-7(Hazardous Substances Data)
Toxicity: A tertiary amine tricyclic antidepressant that is thought to exert its therapeutic effect by inhibiting the reuptake of serotonin and norepinephrine centrally. A major metabolite is N-desmethylimipramine (desipramine), also used as an antidepressant drug. Desipramine differs from imipramine in being a better blocker of norepinephrine, rather than serotonin, uptake. Side effects, including sedation and drowsiness, dry mouth, urinary retention, constipation, and orthostatic hypotension, are probably due to the anticholinergic, anti-α-adrenergic, and antihistaminergic receptor-blocking properties. Imipramine should not be used in conjunction with a monoamine oxidase inhibitor or other treatment that increases catecholamine concentrations (e.g., drugs containing sympathomimetic amines). Imipramine should be avoided in patients with cardiovascular disease or seizure disorder, or in those who may abuse alcohol, as imipramine lowers seizure threshold, can produce cardiovascular toxicity and may potentiate the effects of alcohol. Imipramine intoxication can include CNS abnormalities (e.g., drowsiness, stupor, coma, and extrapyramidal symptoms), cardiac arrhythmia, and respiratory depression. Children appear to be particularly vulnerable to the cardiotoxic and seizure-inducing effects of high doses of imipramine. The oral LD50 in female rats is 305 mg/kg.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

H370Causes damage to organs

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: I7250-25
Product name: Imipramine
Packaging: 500ul
Price: $306
Updated: 2021/12/16

Matrix Scientific

Product number: 099653
Product name: 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Purity: 95+%
Packaging: 1g
Price: $240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006755
Product name: IMIPRAMINE
Purity: 95.00%
Packaging: 1G
Price: $255.15
Updated: 2021/12/16

Matrix Scientific

Product number: 099653
Product name: 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Purity: 95+%
Packaging: 5g
Price: $819
Updated: 2021/12/16

Chemtos

Product number: I-8190
Product name: Imipraminelabeledd4Hydrochloride
Packaging: 10mg
Price: $1100
Updated: 2021/12/16

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IMIPRAMINE Chemical Properties,Usage,Production

Originator

Tofranil,Ciba Geigy,France,1959

Uses

Imipramine is used in depression of various etiology accompanied by motor clumsiness and enuresis in children and Parkinson’s disease.

Uses

antidepressant

Definition

ChEBI: Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. It has a role as an adrenergic uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an antidepressant. It derives from a hydride of a 5H-dibenzo[b,f]azepine.

Manufacturing Process

20 parts of imino dibenzyl are dissolved in 100 parts by volume of absolutely dry benzene. A suspension of 4 parts NaNH2 in 50 parts by volume of absolute benzene are then added dropwise at 50° to 60°C after which the mixture is boiled for an hour under reflux. 13 parts of 3-dimethylamino n_x0002_propyl chloride are then added dropwise at 40° to 50°C and the mixture is boiled for 10 hours under reflux. After cooling, the benzene solution is thoroughly washed with water, whereupon the basic constituents are extracted with dilute hydrochloric acid.
The hydrochloric extract is then made alkaline and the separated base is extracted with ether. After drying, the solvent is evaporated and the residue is distilled in the high vacuum, whereby the N-(3-dimethylaminopropyl)-imino dibenzyl passes over at a temperature of 160°C under 0.1 mm pressure. The chlorohydrate with a melting point of 174° to 175°C is obtained therefrom with alcoholic hydrochloric acid.

brand name

Janimine (Abbott); Pramine (Alra); Presamine (Sanofi Aventis); Tofranil (Novartis); Tofranil (Tyco).

Therapeutic Function

Antidepressant

Mechanism of action

Besides being used in the clinical treatment of depression, imipramine also has been used for the treatment of functional enuresis in children who are at least 6 years of age (25 mg daily administered 1 hour before bedtime, not to exceed 2.5 mg/kg daily).

Clinical Use

Imipramine is a 10,11-dihydrodibenzazepine tertiary amine TCA that is marketed as hydrochloride and pamoate salts, both of which are administered orally. Although the hydrochloride salt may be administered in divided daily doses, imipramine's long duration of action suggests that the entire oral daily dose may be administered at one time.On the other hand, imipramine pamoate usually is administered as a single daily oral dose.

Synthesis

Imipramine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f] azepine (7.1.1), is synthesized by the alkylation of 10,11-dihydro-5H-dibenz[b,f]azepine using 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].

IMIPRAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

Imipramine hydrochloride

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IMIPRAMINE Suppliers

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View Lastest Price from IMIPRAMINE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine 50-49-7
Price: US $1.99/Kg/Bag
Min. Order: 100g
Purity: 99%
Supply Ability: 30tons
Release date: 2021-12-09

50-49-7, IMIPRAMINERelated Search:

TRIMIPRAMINE MALEATE SALT Clomipramine Clomipramine hydrochloride IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D,Imipramine-d3 hydrochloride Imipramine N-Oxide Monohydrate Imipramine hydrochloride MOSAPRAMINE Carpipramine TRIMIPRAMINE IMIPRAMINE LOFEPRAMINE Cianopramine carpipramine dihydrochloride Imipramine-D6 Imipramine, demethyl- Miboplatin Iminodibenzyl 2-Hydroxy Imipramine

IM

Imidobenzyle

Imipramina

Imiprin

Imizin

Imizine

Imizinum

Impramine

Intalpram

Iramil

Irmin

Melipramin

Melipramine

N-(3-Dimethylaminopropyl)-o-iminodibenzyl

N-(gamma-Dimethylaminopropyl)iminodibenzyl

Nelipramin

Prazepine

Promiben

Psychoforin

SK-Pramine

Surplix

Timolet

Tofranil (free base)

Trimipramine BP Impurity D

Tofranil, base

Tofraniln A

3-(10,11-dihydrodibenz(b,f)azepin-5-yl)propyldimethylamine

N-[γ-Dimethylaminopropyl] iminodibenzyl

IMIPRAMINE,1.0MG/MLINMETHANOL

IMIPRAMINE

AURORA KA-7708

1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine

10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine

2,2'-(3-Dimethylaminopropylimino)bibenzyl

2,2'-(3-Dimethylaminopropylimino)dibenzyl

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine

5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine

5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine

5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-

5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-

5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-

Antideprin

Berkomine

Censtim

Censtin

Declomipramine

Dimipressin

DPID

Dynaprin

Eupramin

Imipramine (base and/or unspecified salts)

N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine

10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-(1-propanamine)

3-(4a,5-dihydro-4H-dibenzo[b,f]azepin-10-yl)-N,N-diMethylpropan-1-aMine

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

Clomipramine HCl EP Impurity B

Imipramine for system suitability CRS

Imipramine (Clomipramine EP Impurity B)