AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2

Product Name: AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2
CAS No.: 200959-48-4
Chemical Name: AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2
Synonyms: Ac-RYYRIK-NH;AC-RYYRIK-NH2;Ac-RYYRIK amide;ACETYL-RYYRIK, AMIDE;AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2;N2-Acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-isoleucyl-L-lysinamide;L-Lysinamide, N2-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-isoleucyl-
CBNumber: CB1733969
Molecular Formula: C44H70N14O9
Formula Weight: 939.11
MOL File: 200959-48-4.mol

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AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 9.82±0.15(Predicted)

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1239
Product name: Ac-RYYRIK-NH2
Packaging: 1
Price: $156
Updated: 2021/12/16

Usbiological

Product number: 254519
Product name: Ac-RYYRIK-NH2
Packaging: 1mg
Price: $466
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364154
Product name: Ac-RYYRIK-NH2
Purity: > 95%
Packaging: 5mg
Price: $688.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BIO0000299
Product name: AC-RYYRIK-NH2
Purity: 95.00%
Packaging: 5MG
Price: $692.43
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364154
Product name: Ac-RYYRIK-NH2
Purity: > 95%
Packaging: 10mg
Price: $884
Updated: 2021/12/16

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AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Chemical Properties,Usage,Production

Uses

Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].

Biological Activity

Ac-RYYRIK-NH2 is a potent ORL1 partial agonist as an endogenous ligand of ORL1 in CHO cells (Kd=1.5 nM). Ac-RYYRIK-NH2 is a specific antagonist of G protein activation and competitively antagonizes noc/OFQ-stimulated [35S]-GTPgS-binding G protein in rat meninges and brain sections.

in vivo

Ac-RYYRIK-NH2 (intracerebroventricularly (icv) inhibits spontaneous locomotor activity in mice with an ID ₅₀ of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2

target

Kd: 1.5 nM (ORL1 transfected in CHO cells)

References

[1] H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8. DOI:10.1038/sj.bjp.0702353
[2] H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9. DOI:10.1016/s0196-9781(00)00251-5
[3] C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther.1997 Nov;283(2):735-41. PMID:9353393

AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Suppliers

China 71 Europe 1 France 1 Germany 2 Switzerland 1 United Kingdom 2 United States 8 USA 1 Global 87

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200959-48-4, AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2Related Search:

AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2

ACETYL-RYYRIK, AMIDE

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N2-Acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-isoleucyl-L-lysinamide

200959-48-4

C44H70N14O9

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