ChemicalBook > CAS DataBase List > 2H-1,2,4-Triazole-3-carboxamide

2H-1,2,4-Triazole-3-carboxamide

Product Name
2H-1,2,4-Triazole-3-carboxamide
CAS No.
3641-08-5
Chemical Name
2H-1,2,4-Triazole-3-carboxamide
Synonyms
Ribavirin base;VITAS-BB TBB000340;Ribavirin Impurity 4;Ribavirin EP Impurity D;4-Triazole-3-carboxaMide;Ribavarin EP Impurity D;1,2,4-Triazole-3-formamide;3-formamide 1,2,4-triazole;2H-1,2,4-Triazole-3-carboxa;1,2,4-TRIAZOLE-3-CARBOXAMIDE
CBNumber
CB1738858
Molecular Formula
C3H4N4O
Formula Weight
112.09
MOL File
3641-08-5.mol
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2H-1,2,4-Triazole-3-carboxamide Property

Melting point:
315 °C
Boiling point:
393.4±25.0 °C(Predicted)
Density 
1.537±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Aqueous Base (Slightly), DMSO (Slightly)
form 
Solid
pka
8.50±0.20(Predicted)
color 
White to Off-White
CAS DataBase Reference
3641-08-5(CAS DataBase Reference)
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Safety

HS Code 
2933999552
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2779
Product name
Ribavirin Related Compound D
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg
Packaging
30MG
Price
$499
Updated
2025/07/31
Sigma-Aldrich
Product number
1602740
Product name
Ribavirin Related Compound D
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1130
Updated
2025/07/31
TCI Chemical
Product number
T2402
Product name
1,2,4-Triazole-3-carboxamide
Purity
>97.0%(HPLC)(N)
Packaging
5g
Price
$95
Updated
2025/07/31
TCI Chemical
Product number
T2402
Product name
1,2,4-Triazole-3-carboxamide
Purity
>97.0%(HPLC)(N)
Packaging
25g
Price
$286
Updated
2025/07/31
TRC
Product number
D297365
Product name
N-Des-1-β-D-ribofuranosylRibavirin
Packaging
2.5g
Price
$135
Updated
2021/12/16
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2H-1,2,4-Triazole-3-carboxamide Chemical Properties,Usage,Production

Uses

N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Definition

ChEBI: 1,2,4-triazole-3-carboxamide is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by an aminocarbonyl group at position 3. It is the major catabolite and aglycon of ribavirin. It has a role as a human urinary metabolite and a drug metabolite. It is a member of triazoles, a primary carboxamide, a monocarboxylic acid amide and an aromatic amide.

Synthesis

515-96-8

16694-46-5

3641-08-5

GENERAL STEPS: Methylimine ethyl ester hydrochloride (34.5 g, 0.315 mol) and 100 mL of formamide were added to a 250 mL three-necked flask at room temperature, followed by the addition of sodium ethoxide (21.4 g, 0.315 mol) and stirred for 10 min. Next, 2-hydrazino-2-oxoacetamide (10.8 g, 0.105 mol) was added, and the reaction mixture was heated to 130 °C for 10 h. The reaction pressure was maintained at 10 MPa. The progress of the reaction was monitored by liquid chromatography, and the reaction was stopped after confirming the complete conversion of 2-hydrazino-2-oxoacetamide. After the reaction mixture was cooled to room temperature, the precipitated solid was collected by filtration, washed with water and dried. The final 1,2,4-triazolecarboxamide white solid 9.2 g was obtained in 78.2% yield.

References

[1] Patent: CN108794413, 2018, A. Location in patent: Page/Page column 4-6

2H-1,2,4-Triazole-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2H-1,2,4-Triazole-3-carboxamide manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2H-1,2,4-Triazole-3-carboxamide 3641-08-5
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Shaanxi Dideu Medichem Co. Ltd
Product
2H-1,2,4-Triazole-3-carboxamide 3641-08-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-07-15
Career Henan Chemical Co
Product
2H-1,2,4-Triazole-3-carboxamide 3641-08-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-31

3641-08-5, 2H-1,2,4-Triazole-3-carboxamideRelated Search:

N-TERT-BUTYL-3-ISOPROPYL-5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOLE-1-CARBOXAMIDE 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide N-TERT-BUTYL-3-(2-HYDROXYPROPAN-2-YL)-5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOLE-1-CARBOXAMIDE 5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOLE-4-CARBOXAMIDE,5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOLE-4-CARBOXAMIDE Rufinamide Ribavirin TARIBAVIRIN 1H-1,2,4-Triazole-3-carboxamide N-(2,4-DICHLOROPHENYL)-1-(2,4-DIFLUOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE N-(3,4-DIFLUOROPHENYL)-5-METHYL-1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 5-METHYL-N,1-BIS[3-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE,5-METHYL-N,1-BIS[3-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 1-(2,4-DIFLUOROPHENYL)-5-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE N,1-BIS(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE,N,1-BIS(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE N,1-BIS(2,4-DIFLUOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE,N,1-BIS(2,4-DIFLUOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 1-(2,4-DIFLUOROPHENYL)-N-(4-FLUOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 1-(4-CHLOROPHENYL)-5-METHYL-N-(4-METHYLPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 1-(4-CHLOROPHENYL)-N-(4-METHOXYPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 1-(2,4-DIFLUOROPHENYL)-N-ISOPROPYL-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE

  • 1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID AMIDE
  • 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE
  • 1,2,4-TRIAZOLE-3-CARBOXAMIDE
  • 2H-1,2,4-Triazole-3-carboxamide
  • 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 98.5%
  • 1,2,4-TRIAZOLE-3-CARBOXYAMIDE
  • 3-methylformamide-1,2,4-triazone
  • 1H-1,2,4-Triazole-5-carboxamide
  • VITAS-BB TBB000340
  • 1,2,4-Triazole-3-formamide
  • 2H-1,2,4-Triazole-5-carboxamide
  • Ribavirin base
  • 4-Triazole-3-carboxaMide
  • 3-Carbamoyl-1H-1,2,4-triazole
  • Ribavirin Related Compound D (15 mg) (1H-1,2,4-triazole-3-carboxamide)
  • 3-Carbamoyl-1H-1,2,4-triazole, 3-(Aminocarbonyl)-1H-1,2,4-triazole
  • Ribavirin Related CoMpound D
  • N-Des-1-β-D-ribofuranosyl Ribavirin
  • Ribavirin EP Impurity D
  • 2H-1,2,4-Triazole-3-carboxa
  • Ribavarin EP Impurity D
  • Ribavirin Impurity 4
  • 1H-1,2,4-Triazole-3-formamide
  • 3-formamide 1,2,4-triazole
  • 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE (CAS:3641-08-5)
  • Ribavirin Related Compound D (1H-1,2,4-triazole-3-carboxamide) (1602740)
  • Ribavirin USP Related Compound D
  • 2H-1,2,4-Triazole-3-carboxamide CAS NO.3641-08-5
  • N-Des-1-Beta-D-ribofuranosyl Ribavirin
  • H-1,2,4-Triazole-3-carboxamide
  • 3641-08-5
  • 641-08-5
  • 3641-08-05
  • 3641-8-5
  • 636-10-6