4-BROMO-3-CHLORO-BENZALDEHYDE
Uses- Product Name
- 4-BROMO-3-CHLORO-BENZALDEHYDE
- CAS No.
- 120077-69-2
- Chemical Name
- 4-BROMO-3-CHLORO-BENZALDEHYDE
- Synonyms
- 4-BrMo-3-chlorobenzaldehyde;3-chloro4-bromo-benzaldehyde;4-BROMO-3-CHLORO-BENZALDEHYDE;Benzaldehyde, 4-bromo-3-chloro-;4 - broMine - 3 - chlorobenzene forMaldehyde
- CBNumber
- CB1746514
- Molecular Formula
- C7H4BrClO
- Formula Weight
- 219.46
- MOL File
- 120077-69-2.mol
4-BROMO-3-CHLORO-BENZALDEHYDE Property
- Melting point:
- 52 °C
- Boiling point:
- 281.3±25.0 °C(Predicted)
- Density
- 1.698±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C7H4BrClO/c8-6-2-1-5(4-10)3-7(6)9/h1-4H
- InChIKey
- LDYVDYZLCRUOTM-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(Br)C(Cl)=C1
- CAS DataBase Reference
- 120077-69-2
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683588
- Product name
- 4-Bromo-3-chlorobenzaldehyde
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B683588
- Product name
- 4-Bromo-3-chlorobenzaldehyde
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 119210
- Product name
- 4-Bromo-3-chlorobenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- 119210
- Product name
- 4-Bromo-3-chlorobenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- FB33416
- Product name
- 4-Bromo-3-chlorobenzaldehyde
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
4-BROMO-3-CHLORO-BENZALDEHYDE Chemical Properties,Usage,Production
Uses
4-Bromo-3-chlorobenzaldehyde is a pharmaceutical intermediate that can be obtained by reducing 4-bromo-3-chlorobenzoic acid to (4-bromo-3-chlorophenyl)methanol and then oxidizing it.
Synthesis
1235711-34-8
120077-69-2
General procedure for the synthesis of 4-bromo-3-chloro-N-methoxy-N-methylbenzamide as raw material for 4-bromo-3-chlorobenzaldehyde: 4-bromo-3-chloro-N-methoxy-N-methylbenzamide (1.80 g, 6.46 mmol) was dissolved in anhydrous tetrahydrofuran (32 mL) in a 10 mL single-necked round-bottomed flask under argon protection. The reaction system was cooled to -78 °C and 1M diisobutylaluminum hydride solution (8.4 mL, 8.40 mmol) was slowly added dropwise. The reaction temperature was maintained at -78 °C and the reaction mixture was stirred for 1 hour. Upon completion of the reaction, the reaction was quenched with 50 mL of water, followed by extraction of the aqueous layer with ethyl acetate (3 x 50 mL). The organic layers were combined and washed sequentially with 1N hydrochloric acid solution (30 mL), water (30 mL) and brine (30 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting product was dried under high vacuum to give a yellow solid 4-bromo-3-chlorobenzaldehyde (1.18 g, 84% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 9.98 (s, 1H), 8.11 (d, 1H, J = 1.9 Hz), 8.02 (AB system, 1H, J = 8.2 Hz), 7.77 (dd, 1H, J = 1.9 Hz, 8.2 Hz).
References
[1] Patent: EP2208725, 2010, A1. Location in patent: Page/Page column 13
4-BROMO-3-CHLORO-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-3-CHLORO-BENZALDEHYDE Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 4-BROMO-3-CHLORO-BENZALDEHYDE manufacturers
- Product
- 4-bromo-3-chlorobenzaldehyde 120077-69-2
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-14
- Product
- 4-BROMO-3-CHLORO-BENZALDEHYDE 120077-69-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 4-BROMO-3-CHLORO-BENZALDEHYDE 120077-69-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09