2,4-Dichloro-1,3,5-triazine
- Product Name
- 2,4-Dichloro-1,3,5-triazine
- CAS No.
- 2831-66-5
- Chemical Name
- 2,4-Dichloro-1,3,5-triazine
- Synonyms
- oro-1,3,5-triazine;Dichloro-s-triazine;2,4-dichlorotriazine;2,4-Dichloro-s-triazine;2,4-DICHLORO-1,3,5-TRIAZINE;1,3,5-Triazine,2,4-dichloro-;2,4-Dichloro-1,3,5-triazine>2,4-Dichloro-1,3,5-Triazine pure, 98%
- CBNumber
- CB1748811
- Molecular Formula
- C3HCl2N3
- Formula Weight
- 149.97
- MOL File
- 2831-66-5.mol
2,4-Dichloro-1,3,5-triazine Property
- Melting point:
- 54.0 to 58.0 °C
- Boiling point:
- 102°C/75mmHg(lit.)
- Density
- 1.612±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -1.24±0.10(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C3HCl2N3/c4-2-6-1-7-3(5)8-2/h1H
- InChIKey
- OMRXVBREYFZQHU-UHFFFAOYSA-N
- SMILES
- N1=CN=C(Cl)N=C1Cl
- CAS DataBase Reference
- 2831-66-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933698090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D4891
- Product name
- 2,4-Dichloro-1,3,5-triazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- D4891
- Product name
- 2,4-Dichloro-1,3,5-triazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $144
- Updated
- 2025/07/31
- Product number
- D435995
- Product name
- 2,4-Dichloro-1,3,5-triazine
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D435995
- Product name
- 2,4-Dichloro-1,3,5-triazine
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR3282
- Product name
- 2,4-Dichloro-1,3,5-triazine
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
2,4-Dichloro-1,3,5-triazine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
2,4-Dichloro-1,3,5-triazine is used as an intermediate in organic synthesis and pharmaceutical intermediates, and it is an intermediate in the preparation of bromhexine impurities.
Preparation
2,4-Dichloro-1,3,5-triazine can be synthesized by halogenation of 1,3,5-Triazine with chlorine.
Synthesis
1934-75-4
68-12-2
2831-66-5
General procedure for the synthesis of 2,4-dichloro-1,3,5-triazine from sodium dicyandiamide and N,N-dimethylformamide: Sodium dicyandiamide (3.0 g, 33.70 mmol) was dissolved in water (13 ml) and the solution was transferred to a flask containing concentrated hydrochloric acid. Hydrochloric acid (15 ml) was added slowly at -78°C. The reaction mixture was stirred at -78°C for 15 min, followed by warming to -35°C and continued stirring for 15 min. After that, the mixture was cooled to 0 °C and the precipitate was collected by filtration. Another flask containing N,N-dimethylformamide (10 ml) was prepared at room temperature to which phosphorous trichloride (1.84 ml, 19.71 mmol) and N,N-dimethylformamide (1.53 ml, 19.71 mmol) were added dropwise at 0 °C. After brief stirring, the resulting mixture was added to the above precipitate in batches, followed by stirring at room temperature overnight. After completion of the reaction, the reaction was quenched with water and the mixture was extracted with ethyl acetate (30 ml x 3). The residue was purified by silica gel fast column chromatography (eluent: ethyl acetate/hexane=1:4, Rf=0.63) to afford 2,4-dichloro-1,3,5-triazine (0.64 g, yield 13.13%) as a white solid.1H-NMR (300 MHz, CDCl3): δ 8.90 (s, 1H).
References
[1] Patent: WO2017/15400, 2017, A1. Location in patent: Paragraph 0044; 0058
2,4-Dichloro-1,3,5-triazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-1,3,5-triazine manufacturers
- Product
- 2,4-DICHLORO-1,3,5-TRIAZINE 2831-66-5
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10TON
- Release date
- 2018-12-18