(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)

Product Name: (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
CAS No.: 182912-74-9
Chemical Name: (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
Synonyms: IAB5;IAβ5;LPFFD;IA-BETA5;LEU-PRO-PHE-PHE-ASP;H-LEU-PRO-PHE-PHE-ASP-OH;Beta-Sheet Breaker Peptide iAβ5;BETA-SHEET BREAKER PEPTIDE IA-BETA5;[PRO18, ASP21] BETA-AMYLOID (17-21);BETA-SHEET BREAKER PEPTIDE IA-BETA5P
CBNumber: CB1755202
Molecular Formula: C33H43N5O8
Formula Weight: 637.72
MOL File: 182912-74-9.mol

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(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Property

Boiling point:: 980.0±65.0 °C(Predicted)
Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: ≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic
form: solid
pka: 2.88±0.10(Predicted)
color: White to off-white
Sequence: Leu-Pro-Phe-Phe-Asp

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A1005
Product name: Beta-SheetBreakerPeptideiAβ5
Packaging: 5mg
Price: $45
Updated: 2021/12/16

ApexBio Technology

Product number: A1005
Product name: Beta-SheetBreakerPeptideiAβ5
Packaging: 10mg
Price: $75
Updated: 2021/12/16

ApexBio Technology

Product number: A1005
Product name: Beta-SheetBreakerPeptideiAβ5
Packaging: 25mg
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000210
Product name: [PRO18,ASP21]BETA-AMYLOID(17-21),IAB5
Purity: 95.00%
Packaging: 1MG
Price: $588.19
Updated: 2021/12/16

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(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Chemical Properties,Usage,Production

Uses

β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

in vivo

β-Sheet Breaker Peptide iAβ5 (100 nmol/rat; Intra-amygdala injection; 7 days) coinjected with Aβ1-42 (5 nmol) into in the rat amygdala, blocks Aβ1-42 neurotoxicity in tissue culture, and amyloid fibril formation in the rat model^[1].
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat, 200 nmol/rat; Intra-amygdaloid injection; 7 days) followed by Aβ1-42 (5 nmol), induces disassembly of pre-existing Aβ fibrils in vivo, and leads to a reversal or prevention of Aβ-induced histopathological changes in rat model^[2].

References

[1] Soto C, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med. 1998 Jul;4(7):822-6. DOI:10.1038/nm0798-822
[2] Sigurdsson EM, et al. In vivo reversal of amyloid-beta lesions in rat brain. J Neuropathol Exp Neurol. 2000 Jan;59(1):11-7. DOI:10.1093/jnen/59.1.11
[3] Okada Y, et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Org Lett. 2015 Sep 4;17(17):4264-7. DOI:10.1021/acs.orglett.5b02057

(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Preparation Products And Raw materials

Raw materials

Preparation Products

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(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Suppliers

China 45 France 1 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 1 United States 7 Global 57

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
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Shanghai Hanhong Scientific Co.,Ltd.

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Email: info@hanhongsci.com
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Chemsky（shanghai）International Co.,Ltd.

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BOC Sciences

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Country: United States
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Bide Pharmatech Ltd.

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Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
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Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
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Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
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Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
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182912-74-9, (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)Related Search:

Pro31] – beta – Amyloid (1 – 42),Human (PRO34)-NEUROPEPTIDE Y (PORCINE) Abeta12-28P [Pro34]Peptide YY, PYY, human H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH ACETYL-(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) AMIDE (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) H-PHE-ASP-OH

LPFFD

BETA-SHEET BREAKER PEPTIDE IA-BETA5P

BETA-SHEET BREAKER PEPTIDE IA-BETA5

(PRO18,ASP21)AMYLOID BETA PROTEIN*FRAGMENT (17-21)

[pro18, asp21]-amyloid β protein fragment 17-21 trifluoroacetate salt

LEU-PRO-PHE-PHE-ASP

H-LEU-PRO-PHE-PHE-ASP-OH

IA-BETA5

IAB5

A-BETA42 FIBRILLOGENESIS INHIBITOR I

AMYLOID BETA42 FIBRILLOGENESIS INHIBITOR I

[Pro18, Asp21] β - Amyloid (17 - 21), iAb5

[Pro18, Asp21] beta-Amyloid (17-21), iAb5

[Pro18, Asp21]-AMyloid beta Protein FragMent 17-21 trifluoroacetate salt

(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)

[PRO18, ASP21]AMYLOID-BETA PROTEIN (17-21), HUMAN, MOUSE, RAT

[PRO18, ASP21]-AMYLOID B PROTEIN FRAGMENT 17-21 TRIFLUOROACETATE SALT

[PRO18, ASP21] BETA-AMYLOID (17-21)

L-Aspartic acid, L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-

Beta-Sheet Breaker Peptide iAβ5

IAβ5

(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) USP/EP/BP

(Pro18,Asp21)-Amyloid b-Protein (17-21) trifluoroacetate salt

(Pro18,Asp21)-Amyloid β-Protein (17-21)

(Pro1?,Asp21)-Amyloid β-Protein (17-21) trifluoroacetate salt

(Pro??,Asp??)-Amyloid β-Protein (17-21)

β-Sheet Breaker Peptide iAβ5 (5 mg vial)

L-Leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartic acid

182912-74-9

C33H43N5O8

Biochemicals and Reagents

Amyloid beta Protein Fragments

BioChemical

Amino Acids and Peptides

Neurodegenerative Disease Peptides

Peptides

peptide

Alzheimers and Neurodegenerative Disease Research

Amyloid beta Protein Fragments

Amyloid β Protein FragmentsNeuropeptides

Neurodegenerative Disease Peptides

β Amyloid Peptides