GALLEIN Property

Melting point:

>300°C

Boiling point:

389.44°C (rough estimate)

Density 

1.2392 (rough estimate)

refractive index 

1.6120 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Solubility Almost insoluble in water, benzene, chloroform; soluble in ethanol, acetone

Colour Index 

45445

pka

5.99(at 25℃)

form 

powder

color 

Brownish-red

PH Range

Yellow (3.8) to rose-red (6.6);Pink (10.6) to violet (13.0)

λmax

526nm

Merck 

14,4344

Stability:

Hygroscopic

Major Application

Organic light emitting devices (OLED), treatment of cancer cells, diagnosis and treatment of amyloidosis, cancer chemo preventive activity, inhibition of influenza virus, semiconductors, photoresists, lithographic printing plates, method for ozone determination, treatment of wastewater, determination of silver, nail polish, monitoring sterilization, determination of proteins, induce apoptosis in cancer cells, treatement of cancer cells, antiHIV agent, cancer chemopreventive activity, drug design

CAS DataBase Reference

2103-64-2

EPA Substance Registry System

Gallein (2103-64-2)

Safety

HS Code 

2918.99.4700

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

GALLEIN Chemical Properties,Usage,Production

Uses

Gallein inhibits neutrophil chemotaxis and inflammation, via the disruption of G protein βγ subunit signaling.

Definition

ChEBI: A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.

Preparation

3,4,5-Trihydroxybenzoic acid or Benzene-1,2,3-triol?and Phthalic anhydride?in 190 ~ 200 ℃ reaction (namely GALLEIN), and then into sodium salt namely Alizarine Violet.

Biological Activity

Inhibitor of G protein β γ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

storage

Store at -20°C

Properties and Applications

blue light purple. Free acid soluble in hot water for the big red, soluble in hot ethanol for red light brown. In concentrated sulfuric acid to red light yellow, after dilution with fluorescence red yellow precipitation. Dye aqueous solution to join sodium hydroxide as blue.