3-Hydroxyadamantane-1-acetic acid
- Product Name
- 3-Hydroxyadamantane-1-acetic acid
- CAS No.
- 17768-36-4
- Chemical Name
- 3-Hydroxyadamantane-1-acetic acid
- Synonyms
- Nsc252898;AKOS BC-0174;CHEMBRDG-BB 4013907;IFLAB-BB F3052-0016;LABOTEST-BB LT00077093;(3-Hydroxyadamantanyl)acetic acid;3-HYDROXYADAMANTANE-1-ACETIC ACID;1-Hydroxy-3-adamantaneacetic acid;(3-HYDROXY-1-ADAMANTYL)ACETIC ACID;1-Adamantaneacetic acid, 3-hydroxy-
- CBNumber
- CB1759169
- Molecular Formula
- C12H18O3
- Formula Weight
- 210.27
- MOL File
- 17768-36-4.mol
3-Hydroxyadamantane-1-acetic acid Property
- Melting point:
- 125-129 °C
- Boiling point:
- 375.3±15.0 °C(Predicted)
- Density
- 1.329
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystaline
- pka
- 4.72±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C12H18O3/c13-10(14)6-11-2-8-1-9(3-11)5-12(15,4-8)7-11/h8-9,15H,1-7H2,(H,13,14)
- InChIKey
- JFMDWSCOQLUOCZ-UHFFFAOYSA-N
- SMILES
- C12(CC(O)=O)CC3CC(CC(O)(C3)C1)C2
- CAS DataBase Reference
- 17768-36-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 678651
- Product name
- 3-Hydroxyadamantane-1-acetic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $122
- Updated
- 2023/06/20
- Product number
- H1414
- Product name
- 3-Hydroxy-1-adamantaneacetic Acid
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- H1414
- Product name
- 3-Hydroxy-1-adamantaneacetic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $256
- Updated
- 2025/07/31
- Product number
- 012727
- Product name
- (3-Hydroxy-adamantan-1-yl)-acetic acid
- Packaging
- 500mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 2229-1-73
- Product name
- 3-Hydroxy-1-adamantane acetic acid
- Packaging
- 5G
- Price
- $84
- Updated
- 2021/12/16
3-Hydroxyadamantane-1-acetic acid Chemical Properties,Usage,Production
Chemical Properties
Light yellow powder
Uses
3-Hydroxyadamantane-1-acetic acid is a derivative of adamantane. Its crystal structure has been analyzed through X-ray diffraction, revealing stabilization through intermolecular O-H...O hydrogen bonds that form a chain. The application of adamantane and its derivatives is widespread in medicine. For example, adamantaneamine has demonstrated efficacy in inhibiting influenza A virus exuviation and in easing Parkinsonian symptoms (Lu et al., 1996).
Synthesis
4942-47-6
17768-36-4
General procedure for the synthesis of 3-hydroxy-1-adamantaneacetic acid from 1-adamantaneacetic acid: adamantanecarboxylic acid (1a-1s, 3.5 g) was added in batches to a mixture comprising 2.5-3 or 7 equivalents of MnO2 and 2.5-14 mL of 93% H2SO4, pre-cooled to -30 °C, with the reaction maintained at a temperature of less than 25 °C, under vigorous stirring. The reaction mixture was maintained at this temperature for 0.5-24 hours and subsequently treated with cold water under ice bath cooling. The precipitate was collected by filtration and washed with a small amount of water and butan-1-ol. The product was extracted with butan-1-ol (5 x 2 mL). For the isolation of the products 2j-21 and 2q-2s, it was necessary to adjust the mixture to pH 3-4 with 30% aqueous sodium hydroxide solution prior to extraction. all organic phases were combined, washed sequentially with water, sodium bicarbonate solution, and water, and then dried by azeotropic distillation. Finally, the solvent was removed under reduced pressure on a rotary evaporator and the target product 3-hydroxy-1-adamantaneacetic acid was purified by recrystallization.
References
[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 6, p. 785 - 790
[2] Zh. Org. Khim., 2016, vol. 52, # 6, p. 800 - 805,6
[3] Chemische Berichte, 1968, vol. 101, p. 564 - 573
[4] Russian Journal of Organic Chemistry, 2017, vol. 53, # 7, p. 971 - 976
3-Hydroxyadamantane-1-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Hydroxyadamantane-1-acetic acid manufacturers
- Product
- 3-Hydroxyadamantane-1-acetic acid 17768-36-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-06-19
- Product
- (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID 17768-36-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-11-16
- Product
- (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID 17768-36-4
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-21