DIBENZYL DIISOPROPYLPHOSPHORAMIDITE

Product Name: DIBENZYL DIISOPROPYLPHOSPHORAMIDITE
CAS No.: 108549-23-1
Chemical Name: DIBENZYL DIISOPROPYLPHOSPHORAMIDITE
Synonyms: DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE;DIBENZYL N,N-DIISOPRO;Dibenzyl-N,N-disisopropylphosphoramidite;LABOTEST-BB LT00451623;108549-23-1,108549-23-1;DIBENZYL DIISOPROPYLPHOSPHORAMIDITE;Dibenzyl diisopropylphosphoramidoite;Dibenyl NN diisopropylphosphoramidite;DIBENZYLOXY(DIISOPROPYLAMINO)PHOSPHINE;DIBENZYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE
CBNumber: CB1772267
Molecular Formula: C20H28NO2P
Formula Weight: 345.42
MOL File: 108549-23-1.mol

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DIBENZYL DIISOPROPYLPHOSPHORAMIDITE Property

Boiling point:: 130 °C0.55 mm Hg(lit.)
Density: 1.028 g/mL at 25 °C(lit.)
refractive index: n20/D 1.535(lit.)
Flash point:: 158 °F
storage temp.: 2-8°C
solubility: Soluble in chloroform.
pka: 4.50±0.70(Predicted)
form: Oil
color: Clear Colourless
Water Solubility: THF: soluble(lit.)
acetonitrile: soluble(lit.)
cold water: insoluble(lit.)
dichloromethane: soluble(lit.)
Sensitive: Moisture Sensitive
BRN: 3616864
InChI: InChI=1S/C20H28NO2P/c1-17(2)21(18(3)4)24(22-15-19-11-7-5-8-12-19)23-16-20-13-9-6-10-14-20/h5-14,17-18H,15-16H2,1-4H3
InChIKey: ANPWLBTUUNFQIO-UHFFFAOYSA-N
SMILES: P(N(C(C)C)C(C)C)(OCC1=CC=CC=C1)OCC1=CC=CC=C1
CAS DataBase Reference: 108549-23-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 3-10-21
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 416436
Product name: Dibenzyl N,N-diisopropylphosphoramidite
Purity: technical grade, 90%
Packaging: 5ml
Price: $109.25
Updated: 2025/07/31

Sigma-Aldrich

Product number: 416436
Product name: Dibenzyl N,N-diisopropylphosphoramidite
Purity: technical grade, 90%
Packaging: 25ml
Price: $356.25
Updated: 2025/07/31

TCI Chemical

Product number: D2624
Product name: Dibenzyl N,N-Diisopropylphosphoramidite
Purity: >98.0%(T)
Packaging: 5g
Price: $237
Updated: 2025/07/31

TRC

Product number: D417500
Product name: Dibenzyl N,N-diisopropylphosphoramidite
Packaging: 5g
Price: $150
Updated: 2021/12/16

Chem-Impex

Product number: 12547
Product name: Dibenzyl-N,N-diisopropylphosphoramidite,99%(PNMR)
Purity: 99%(PNMR)
Packaging: 25G
Price: $156.8
Updated: 2021/12/16

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DIBENZYL DIISOPROPYLPHOSPHORAMIDITE Chemical Properties,Usage,Production

Description

Dibenzyl diisopropylphosphoramidite is a versatile phosphitylating agent.

Chemical Properties

Clear Colourless Liquid

Uses

A versatile phosphitylating agent

Uses

Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.

Synthesis

921-26-6

100-51-6

108549-23-1

General procedure for the synthesis of diphenyl N,N'-diisopropylphosphoramidite from dichloro-N,N-diisopropylphosphoramidite and benzyl alcohol: 42 g (207.92 mmol) of dichloro-N,N-diisopropylphosphoramidite was placed in a 500 mL round-bottomed flask, and 300 mL of anhydrous tetrahydrofuran was added, and dissolved by stirring. Subsequently 66 mL (455.44 mmol, 46 g) of anhydrous triethylamine was added. The flask was cooled to 0°C in an ice-salt bath and 45 mL (416.67 mmol, 45 g) of anhydrous benzyl alcohol was added slowly and dropwise under nitrogen protection, keeping the reaction temperature close to 0°C. Upon completion of the reaction, the suspension was added dropwise and the formation of a white solid was observed. The reaction mixture was removed from the ice bath, returned to room temperature and stirring was continued for 3 hours. After stopping stirring, it was allowed to stand for 10 minutes for filtration and the solid was washed with tetrahydrofuran. The filtrate was collected and the solvent was removed by rotary evaporation to give the crude product. Without column chromatographic purification, 54.0 g of the oily product was obtained directly in 75.3% yield.

References

[1] Tetrahedron, 1991, vol. 47, # 26, p. 4709 - 4722
[2] Patent: CN102977145, 2017, B. Location in patent: Paragraph 0196; 0197
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 11, p. 1239 - 1246
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 23, p. 3918 - 3927
[5] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7719 - 7726

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE Preparation Products And Raw materials

Raw materials

Benzyl alcohol Toluene Triethylamine Diisopropylamine Phosphorus trichloride Tetrahydrofuran Ethyl acetate Dichloromethane

Preparation Products

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DIBENZYL DIISOPROPYLPHOSPHORAMIDITE Suppliers

Americas 1 Canada 3 China 187 Europe 2 France 1 Germany 5 India 6 Japan 4 Switzerland 1 United Kingdom 6 United States 25 Global 241

Suzhou Highfine Biotech Co., Ltd

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J & K SCIENTIFIC LTD.

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View Lastest Price from DIBENZYL DIISOPROPYLPHOSPHORAMIDITE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Dibenzyl diisopropylphosphoramidite 108549-23-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: DIBENZYL DIISOPROPYLPHOSPHORAMIDITE 108549-23-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Hebei Yanxi Chemical Co., Ltd.

Product: Dibenzyl diisopropylphosphoramidite 108549-23-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-14

108549-23-1, DIBENZYL DIISOPROPYLPHOSPHORAMIDITERelated Search:

N-Isopropylbenzylamine N-Methyl-2-pyrrolidone Zidovudine DIETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE BIS[1-(2-NITROPHENYL)ETHYL] N,N-DIISOPROPYLPHOSPHORAMIDITE DIBENZYL N,N-DIMETHYLPHOSPHORAMIDITE Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite DIBENZYL DIETHYLPHOSPHORAMIDITE DIBENZYL DIISOPROPYLPHOSPHORAMIDITE

N-[bis(phenylmethoxy)phosphanyl]-N-propan-2-yl-propan-2-amine

N-[bis(phenylmethoxy)phosphanyl]-N-propan-2-ylpropan-2-amine

Dibenzyl-N,N-disisopropylphosphoramidite

Dibenzyl N,N-diisopropylphosphoramidite, 95+%

Dibenzyl N,N-diisopropylphosphoramidite, tech 90%

DIBENZYL N,N-DIISOPRO

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE

DIBENZYLOXY(DIISOPROPYLAMINO)PHOSPHINE

DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE

DIBENZYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE

LABOTEST-BB LT00451623

bis(benzyloxy)(diisopropylamino)phosphine

β-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite

PHOSPHORAMIDOUS ACID, N,N-BIS(1-METHYLETHYL)-, BIS(PHENYLMETHYL) ESTER

DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE, TECHNICAL GRADE, 90%

Dibenzyl N,N-diisopropylphosphoramidite,90+%

N,N-Bis(1-methylethyl)phosphoramidous acid bis(phenylmethyl) ester

bis(benzyloxy)phosphino-diisopropyl-amine

Dibenzyl diisopropylphosphoramidite, 90%, for synthesis

DibenzylN,N-Diisopropylphosphoramidite&gt

Dibenzyl N,N-Diisopropylphosphoramidite,98%

Dibenyl NN diisopropylphosphoramidite

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE USP/EP/BP

108549-23-1,108549-23-1

Dibenzyl diisopropylphosphoramidoite

Dibenzyl <i>N</i>,<i>N</i>-diisopropylphosphoramidite

108549-23-1

08549-23-1

C20H28NO2P

CH32CH2NPOCH2C6H52

Building Blocks

Phosphorylation

DNA / RNA Synthesis

Phosphorylating Agents

Organic Building Blocks

Phosphoramidites

Phosphorus Compounds

OLED materials,pharm chemical,electronic

Organic Building Blocks

Phosphoramidites

Phosphorus Compounds

Phospholipids - 13C & 2H

Biochemistry

Nucleosides, Nucleotides & Related Reagents

Phosphorylating and Phosphorothioating Agents

Phosphorylation

Protecting Agents, Phosphorylating Agents & Condensing Agents

Synthetic Organic Chemistry

Phosphorylating and Phosphitylating Agents

SiChem

OLED