2,4,6-TRIMETHYLPHENYL ISOCYANATE Property

Melting point:

44-48 °C(lit.)

Boiling point:

218-220°C

Flash point:

220 °F

storage temp. 

2-8°C

Water Solubility 

It hydrolyzes in water.

Sensitive 

Moisture Sensitive

BRN 

2085601

CAS DataBase Reference

2958-62-5

Safety

Hazard Codes 

Xn

Risk Statements 

22-36-42-36/37/38-23/25

Safety Statements 

26-60-45-36/37-22-20-9-4

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

II

HS Code 

29291090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P405Store locked up.

2,4,6-TRIMETHYLPHENYL ISOCYANATE Chemical Properties,Usage,Production

Uses

2,4,6-Trimethylphenyl isocyanate is used as an organic chemical synthesis intermediate.

Preparation

A solution of Boc2O (619 mg, 2.84 mmol) in acetonitrile (2 mL) was treated successively with a solution of 4-dimethylaminopyridine (33 mg, 0.27 mmol) in acetonitrile (2 mL) and a solution of 348 (365 mg, 2.7 mmol) in acetonitrile (2 mL). The reaction mixture was stirred vigorously for 10 min. After the addition of concentrated sulfuric acid in acetonitrile (40% solution, ρ= 1:03 g cm-3, 0.47 mL), the resulting mixture was stirred for 5 min. Water (0.47 mL) was then added, and the mixture was stirred for a further 5 min. The reaction mixture was then poured into an equal volume of water. The solution was extracted three times with hexane, and the combined hexane layers were dried over magnesium sulfate. Removal of the solvent in vacuo afforded mesityl isocyanate 349 (420 mg, 97%) as colorless crystals; mp 42 °C.