METHYLSULFONYLACETONE Property

Melting point:

48-52 °C (lit.)

Boiling point:

300.8±25.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

powder or crystals

Water Solubility 

Insoluble in water.

BRN 

1754113

CAS DataBase Reference

5000-46-4(CAS DataBase Reference)

Safety

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29302000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METHYLSULFONYLACETONE Chemical Properties,Usage,Production

Uses

Methylsulfonylacetone is used as reactant for Stereoselective preparation of chiral cyclic ketones. It is used in the Preparation of poly-substituted pyridines. It aids for Gold-catalyzed Friedlander cyclocondensation reaction. It is used as reactant in Radical homoallylation reactions, multicomponent cyclocondensation with aldehydes and aminoazoles.

General Description

Methanesulfonylacetone is a sulfonyl group-containing active methylene compound. It can react with Baylis–Hillman acetates in dimethylformamide/potassium carbonate system to form ortho-hydroxyacetophenone derivatives.