NQO1 substrate

Product Name: NQO1 substrate
CAS No.: 2304503-05-5
Chemical Name: NQO1 substrate
Synonyms: NQO1 substrate;NQO1 substrate, 10 mM in DMSO;NQO-1 substrate|||NQO1 substrate;9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 6,7-difluoro-9-oxo-
CBNumber: CB18042957
Molecular Formula: C13H2F2N4O
Formula Weight: 268.18
MOL File: 2304503-05-5.mol

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NQO1 substrate Property

Boiling point:: 593.0±50.0 °C(Predicted)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (466.10 mM)
pka: -10.35±0.20(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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NQO1 substrate Chemical Properties,Usage,Production

Uses

NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].

References

[1] Wu X, et al. Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61(24):11280-11297. DOI:10.1021/acs.jmedchem.8b01424

NQO1 substrate Preparation Products And Raw materials

Raw materials

Preparation Products

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NQO1 substrate Suppliers

CHINA 10 United States 3 Global 13

TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Sangon Biotech (Shanghai) Co.,Ltd.

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Biosynth Biological Technology (Suzhou) Co Ltd

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TargetMol Chemicals Inc.

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Tianjin Baibei Biotechnology Co., Ltd.

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Guangzhou Jingyan Biotechnology Co., Ltd.

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2304503-05-5, NQO1 substrateRelated Search:

NQO1 substrate

9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 6,7-difluoro-9-oxo-

NQO-1 substrate|||NQO1 substrate

NQO1 substrate, 10 mM in DMSO

2304503-05-5