DWP14012 hydrochloride
- Product Name
- DWP14012 hydrochloride
- CAS No.
- 1902954-87-3
- Chemical Name
- DWP14012 hydrochloride
- Synonyms
- RMA-44;DWP14012 HCl;DWP-14012 HCl;DWP 14012 HCl;Abeprazan HCl;Fexuprazan HCI;FEXUPRAZAN HCL;DWP14012 hydrochloride;Abeprazan hydrochloride
- CBNumber
- CB18054297
- Molecular Formula
- C19H18ClF3N2O3S
- Formula Weight
- 446.87
- MOL File
- 1902954-87-3.mol
DWP14012 hydrochloride Property
- storage temp.
- -20°C, away from moisture
- form
- Solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
DWP14012 hydrochloride Chemical Properties,Usage,Production
Uses
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1].
Biological Activity
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1]. Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].
in vivo
Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].
References
[1]. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.
DWP14012 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DWP14012 hydrochloride manufacturers
- Product
- Abeprazan hydrochloride 1902954-87-3
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-23
- Product
- FEXUPRAZAN HCL 1902954-87-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 0.99
- Supply Ability
- 5kg
- Release date
- 2025-03-03