ChemicalBook > CAS DataBase List > JNJ-42226314

JNJ-42226314

Product Name
JNJ-42226314
CAS No.
1252765-13-1
Chemical Name
JNJ-42226314
Synonyms
Compound 6g;JNJ-42226314;JNJ42226314,JNJ 42226314;JNJ-42226314, 10 mM in DMSO;1-(4-Fluorophenyl)-5-indolyl][3-[4-(thiazole-2-carbonyl)-1-piperazinyl]-1-azetidinyl]methanone;1-(4-fluorophenyl)-5-{3-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]azetidine-1-carbonyl}-1H-indole;(1-(4-Fluorophenyl)-1H-indol-5-yl)(3-(4-(thiazole-2-carbonyl)piperazin-1-yl)azetidin-1-yl)methanone;Methanone, [4-[1-[[1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl]-3-azetidinyl]-1-piperazinyl]-2-thiazolyl-
CBNumber
CB18054439
Molecular Formula
C26H24FN5O2S
Formula Weight
489.56
MOL File
1252765-13-1.mol
More
Less

JNJ-42226314 Property

Boiling point:
624.9±65.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 2mg/mL, clear
form 
Solid
pka
5.68±0.70(Predicted)
color 
White to off-white
InChIKey
IVOACCSOISMVBL-UHFFFAOYSA-N
SMILES
C(N1CCN(C2CN(C(C3C=CC4=C(C=3)C=CN4C3=CC=C(F)C=C3)=O)C2)CC1)(C1=NC=CS1)=O
More
Less

Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
41115
Product name
JNJ-42226314
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2026/04/30
Cayman Chemical
Product number
41115
Product name
JNJ-42226314
Purity
≥98%
Packaging
5mg
Price
$145
Updated
2026/04/30
Cayman Chemical
Product number
41115
Product name
JNJ-42226314
Purity
≥98%
Packaging
10mg
Price
$240
Updated
2026/04/30
Cayman Chemical
Product number
41115
Product name
JNJ-42226314
Purity
≥98%
Packaging
25mg
Price
$479
Updated
2026/04/30
ChemScene
Product number
CS-0112147
Product name
JNJ-42226314
Purity
99.59%
Packaging
10mg
Price
$580
Updated
2021/12/16
More
Less

JNJ-42226314 Chemical Properties,Usage,Production

Uses

JNJ-42226314 is a competitive, highly selective and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) as well as efficacy in models of neuropathic and inflammatory pain[1].

Biological Activity

Brain penetrant, highly selective and potent reversible inhibitor of monoacylglycerol lipase (MAGL).


JNJ-42226314 is a brain penetrant, highly selective and potent reversible inhibitor of monoacylglycerol lipase (MAGL)(IC50 = 1.1) th at exhibits antinociceptive efficacy in the r at models neuropathic and inflammatory pain. JNJ-42226314 elevates hippocampal 2-arachidonoylglycerol (2-AG) levels and prolongs wakefulness in rats.

in vivo

JNJ-42226314 (i.p.; 3 mg/kg and 30 mg/kg; 120 min) dose-dependently elevates hippocampal 2-AG in vivo[1].
JNJ-42226314 (i.p.; 30 mg/kg)significantly increases total wake time for up to 8 hours afterward, whereas total wake time was only elevated for 2 hr following a 3 mg/kg dose[1].
JNJ-42226314 (i.p.; 30 mg/kg) is antinociceptive in the rat complete Freund’s adjuvant (CFA) model of inflammatory pain[1].
JNJ-42226314 has t1/2 values of 11.4, 27.6, 27.2 min for MAGL in human, mouse and rat, respectively[1].

Animal Model:Male C57Bl/6 mice weighing 20-30g and male Sprague-Dawley rats weighing 300-400 g[1]
Dosage:3 mg/kg and 30 mg/kg
Administration:i.p.; 120 min
Result:Dose-dependently elevated hippocampal 2-AG in vivo.

References

[1] Wyatt RM, et al.Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor.J Pharmacol Exp Ther. 2019 Dec 9. DOI:10.1124/jpet.119.262139

JNJ-42226314 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

JNJ-42226314 Suppliers

China 25 United States 3 Global 28
Anqing YanZhi Pharma Discovery Co.,Ltd.
Tel
18055651951
Email
2272561977@qq.com
Country
China
ProdList
436
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2587
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89689
Advantage
60
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4410
Advantage
58
Nanjing Machido Pharmaceutical Technology Co., Ltd.
Tel
19556085883
Fax
QQ:1494490951
Email
sales@machidopharma.com
Country
China
ProdList
393
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58

1252765-13-1, JNJ-42226314Related Search:


  • JNJ-42226314
  • JNJ42226314,JNJ 42226314
  • Methanone, [4-[1-[[1-(4-fluorophenyl)-1H-indol-5-yl]carbonyl]-3-azetidinyl]-1-piperazinyl]-2-thiazolyl-
  • 1-(4-Fluorophenyl)-5-indolyl][3-[4-(thiazole-2-carbonyl)-1-piperazinyl]-1-azetidinyl]methanone
  • (1-(4-Fluorophenyl)-1H-indol-5-yl)(3-(4-(thiazole-2-carbonyl)piperazin-1-yl)azetidin-1-yl)methanone
  • 1-(4-fluorophenyl)-5-{3-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]azetidine-1-carbonyl}-1H-indole
  • JNJ-42226314, 10 mM in DMSO
  • Compound 6g
  • 1252765-13-1