Azido-PEG8-hydrazide
- Product Name
- Azido-PEG8-hydrazide
- CAS No.
- 2353410-11-2
- Chemical Name
- Azido-PEG8-hydrazide
- Synonyms
- Azido-PEG8-hydrazide;1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosane-27-hydrazide
- CBNumber
- CB18054666
- Molecular Formula
- C19H39N5O9
- Formula Weight
- 481.55
- MOL File
- 2353410-11-2.mol
Azido-PEG8-hydrazide Property
- solubility
- Soluble in Water
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- BP-24118
- Product name
- Azido-PEG8-hydrazideHClSalt
- Purity
- 98%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
Azido-PEG8-hydrazide Chemical Properties,Usage,Production
Description
Azido-PEG8-hydrazide HCl salt is a wter soluble PEG linker containing an azide group and a hydrazide moiety. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond.
Uses
Azido-PEG8-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG8-hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG8-hydrazide manufacturers
- Product
- Azido-PEG8-hydrazide 2353410-11-2
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >98.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-23