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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

Product Name
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
CAS No.
2160546-07-4
Chemical Name
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
Synonyms
BBP398;BBP-398;BBP 398;IACS13909;IACS15509;IACS-15509;IACS 15509;LACS-13909;BBP- 398 (IACS-13909);IACS-13909, 10 mM in DMSO
CBNumber
CB18093166
Molecular Formula
C17H18Cl2N6
Formula Weight
377.27
MOL File
2160546-07-4.mol
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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Property

Boiling point:
577.3±50.0 °C(Predicted)
Density 
1.402±0.06 g/cm3(Predicted)
solubility 
DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form 
Solid
pka
8.00±0.50(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0136474
Product name
IACS-13909
Purity
99.93%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0136474
Product name
IACS-13909
Purity
99.93%
Packaging
10mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0136474
Product name
IACS-13909
Purity
99.93%
Packaging
25mg
Price
$1050
Updated
2021/12/16
DC Chemicals
Product number
020571
Product name
IACS-13909
Packaging
001
Price
$700
Updated
2021/12/16
DC Chemicals
Product number
020571
Product name
IACS-13909
Packaging
003
Price
$2400
Updated
2021/12/16
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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Chemical Properties,Usage,Production

Uses

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers[1].

in vivo

IACS-13909 (70 mg/kg; oral administration; daily; for 21 days) treatment potently suppresses tumor growth in mice, with 100% tumor growth inhibition (TGI) observed following 21 days of dosing[1].

Animal Model:NSG mice (20-28 g) injected with KYSE-520 cells[1]
Dosage:70 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Potently suppressed tumor growth in mice.

References

[1] Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21):4840-4853. DOI:10.1158/0008-5472.CAN-20-1634
[2] BARBARA CZAKO*. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor[J]. Journal of Medicinal Chemistry, 2021, 64 20: 15141-15169. DOI: 10.1021/acs.jmedchem.1c01132

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Suppliers

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2160546-07-4, 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-Related Search:

Glucosamine

  • 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
  • IACS13909
  • LACS-13909
  • BBP 398
  • BBP398
  • BBP-398
  • IACS 15509
  • IACS15509
  • IACS-15509
  • antiproliferative,RTK,IACS13909,inhibit,SHP2,pMEK,anticancer,Inhibitor,MAPK,IACS 13909,pERK,Phosphatase,IACS-13909
  • IACS-13909, 10 mM in DMSO
  • BBP- 398 (IACS-13909)
  • 2160546-07-4
  • C17H18Cl2N6