ChemicalBook > CAS DataBase List > 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

Product Name
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
CAS No.
2160546-07-4
Chemical Name
4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
Synonyms
BBP398;BBP-398;BBP 398;IACS13909;IACS15509;IACS-15509;IACS 15509;LACS-13909;BBP- 398 (IACS-13909);IACS-13909, 10 mM in DMSO
CBNumber
CB18093166
Molecular Formula
C17H18Cl2N6
Formula Weight
377.27
MOL File
2160546-07-4.mol
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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Property

Boiling point:
577.3±50.0 °C(Predicted)
Density 
1.402±0.06 g/cm3(Predicted)
solubility 
DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form 
Solid
pka
8.00±0.50(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0136474
Product name
IACS-13909
Purity
99.93%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0136474
Product name
IACS-13909
Purity
99.93%
Packaging
10mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0136474
Product name
IACS-13909
Purity
99.93%
Packaging
25mg
Price
$1050
Updated
2021/12/16
DC Chemicals
Product number
020571
Product name
IACS-13909
Packaging
003
Price
$2400
Updated
2021/12/16
DC Chemicals
Product number
020571
Product name
IACS-13909
Packaging
001
Price
$700
Updated
2021/12/16
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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Chemical Properties,Usage,Production

Uses

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers[1].

in vivo

IACS-13909 (70 mg/kg; oral administration; daily; for 21 days) treatment potently suppresses tumor growth in mice, with 100% tumor growth inhibition (TGI) observed following 21 days of dosing[1].

Animal Model:NSG mice (20-28 g) injected with KYSE-520 cells[1]
Dosage:70 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Potently suppressed tumor growth in mice.

References

[1] Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21):4840-4853. DOI:10.1158/0008-5472.CAN-20-1634
[2] BARBARA CZAKO*. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor[J]. Journal of Medicinal Chemistry, 2021, 64 20: 15141-15169. DOI: 10.1021/acs.jmedchem.1c01132

4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- Suppliers

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2160546-07-4, 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-Related Search:

Glucosamine

  • 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-
  • IACS13909
  • LACS-13909
  • BBP 398
  • BBP398
  • BBP-398
  • IACS 15509
  • IACS15509
  • IACS-15509
  • antiproliferative,RTK,IACS13909,inhibit,SHP2,pMEK,anticancer,Inhibitor,MAPK,IACS 13909,pERK,Phosphatase,IACS-13909
  • IACS-13909, 10 mM in DMSO
  • BBP- 398 (IACS-13909)
  • 2160546-07-4
  • C17H18Cl2N6