PF-07104091

Product Name: PF-07104091
CAS No.: 2460249-19-6
Chemical Name: PF-07104091
Synonyms: PF-07104091;PF7104091;PF 7104091;PF-7104091;Tagtociclib (PF-07104091);PF07104091, 10 mM in DMSO;(1R,3S)-3-{5-[3-(methoxymethyl)-1-methyl-1H-pyrazole-5-amido]-1H-pyrazol-3-yl}cyclopentyl N-(propan-2-yl)carbamate;(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate;(1R,3S)-3-[3-[[5-(methoxymethyl)-2-methyl-pyrazole-3-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-isopropylcarbamate
CBNumber: CB18097593
Molecular Formula: C19H28N6O4
Formula Weight: 404.47
MOL File: 2460249-19-6.mol

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PF-07104091 Property

Boiling point:: 567.0±50.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
pka: 12.51±0.46(Predicted)
InChIKey: MTNBRBDFNSGQKB-DCHPQEBHNA-N
SMILES: N(C1NN=C([C@H]2CC[C@@H](OC(=O)NC(C)C)C2)C=1)C(C1N(N=C(COC)C=1)C)=O |&1:5,8,r|

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Hazard and Precautionary Statements (GHS)

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PF-07104091 Chemical Properties,Usage,Production

Description

PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2; Ki = 1.16 nM).1 It is selective for Cdk2 over glycogen synthase kinase 3β (GSK3β; Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively).2 In vivo, PF-07104091 (50 mg/kg per day) reduces tumor volume and weight in an HCT116 mouse xenograft model.WARNING This product is not for human or veterinary use.

References

[1] JUN TANG . Anilinopyrazole as selective CDK2 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 18: Pages 2985-2988. DOI: 10.1016/s0960-894x(03)00630-9
[2] LIU Z, YANG Y, SUN X, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53[J]. Molecules, 2024, 33 1. DOI: 10.3390/molecules29030725

PF-07104091 Preparation Products And Raw materials

Raw materials

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PF-07104091 Suppliers

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2460249-19-6, PF-07104091Related Search:

PF-07104091

(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate

(1R,3S)-3-[3-[[5-(methoxymethyl)-2-methyl-pyrazole-3-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-isopropylcarbamate

PF 7104091

PF7104091

PF-7104091

(1R,3S)-3-{5-[3-(methoxymethyl)-1-methyl-1H-pyrazole-5-amido]-1H-pyrazol-3-yl}cyclopentyl N-(propan-2-yl)carbamate

PF07104091, 10 mM in DMSO

Tagtociclib (PF-07104091)

2460249-19-6

C19H28N6O4