Thalidomide-NH-CH2-COOH

Product Name: Thalidomide-NH-CH2-COOH
CAS No.: 927670-97-1
Chemical Name: Thalidomide-NH-CH2-COOH
Synonyms: Thalidomide-NH-CH2-COOH;Thalidomide-4-NH-C1-COOH;6-dioxopiperidin-3-yl)-1;3-dioxoisoindolin-4-yl)glycine;3-dioxoisoindol-4-yl]amino]acetic acid;(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine;2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid;Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid;inhibit,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor,Thalidomide NH CH2 COOH,ThalidomideNHCH2COOH,cereblon,Thalidomide-NH-CH-2-COOH,CRBN,Thalidomide
CBNumber: CB18197022
Molecular Formula: C15H13N3O6
Formula Weight: 331.28
MOL File: 927670-97-1.mol

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Thalidomide-NH-CH2-COOH Property

Boiling point:: 713.9±60.0 °C(Predicted)
Density: 1.637±0.06 g/cm3(Predicted)
solubility: DMSO : 50 mg/mL (150.93 mM; Need ultrasonic)
pka: 3.92±0.10(Predicted)
form: Solid
InChI: InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22)
InChIKey: LRGLFYOYKPSPJQ-UHFFFAOYSA-N
SMILES: C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

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Hazard and Precautionary Statements (GHS)

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Thalidomide-NH-CH2-COOH Chemical Properties,Usage,Production

Definition

Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).

Thalidomide-NH-CH2-COOH Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-NH-CH2-COOH Suppliers

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927670-97-1, Thalidomide-NH-CH2-COOHRelated Search:

[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid

Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

Thalidomide-NH-CH2-COOH

3-dioxoisoindol-4-yl]amino]acetic acid

3-dioxoisoindolin-4-yl)glycine

6-dioxopiperidin-3-yl)-1

(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

inhibit,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor,Thalidomide NH CH2 COOH,ThalidomideNHCH2COOH,cereblon,Thalidomide-NH-CH-2-COOH,CRBN,Thalidomide

2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid

Thalidomide-4-NH-C1-COOH

927670-97-1