ChemicalBook > CAS DataBase List > TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE

TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE

Product Name
TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE
CAS No.
916421-36-8
Chemical Name
TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE
Synonyms
4-(1-Boc-3-azetidinyl)aniline;TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE;3- (4-aminophenyl) azacyclobutane-1-tert-butyl carboxylate;3- (4-aminophenyl) azacyclobutane-1-carboxylic acid tert butyl ester;1-Azetidinecarboxylic acid, 3-(4-aminophenyl)-, 1,1-dimethylethyl ester;tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate , tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate
CBNumber
CB1820863
Molecular Formula
C14H20N2O2
Formula Weight
248.32
MOL File
Mol file
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TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0371124
Product name
TERT-BUTYL-3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$503.1
Updated
2021/12/16
AK Scientific
Product number
2107DN
Product name
Tert-butyl3-(4-aminophenyl)azetidine-1-carboxylate
Packaging
5g
Price
$2085
Updated
2021/12/16
Crysdot
Product number
CD11017111
Product name
tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate
Purity
95+%
Packaging
5g
Price
$2475
Updated
2021/12/16
Crysdot
Product number
CD11017111
Product name
tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate
Purity
95+%
Packaging
10g
Price
$3465
Updated
2021/12/16
Alichem
Product number
916421368
Product name
tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate
Packaging
5g
Price
$3651.5
Updated
2021/12/16
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TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

883901-62-0

916421-36-8

General procedure for the synthesis of tert-butyl 3-(4-aminophenyl)azetidine-1-carboxylate from tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate: 10% Pd/C (0.320 g) and 3-(4-nitrophenyl)tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate (16) (2.14 g, 7.68 mmol) were mixed in a EtOAc (16 mL) solution was suspended under hydrogen atmosphere and the reaction was stirred for 18 hours. Subsequently, 10% Pd/C (1.00 g) was added supplementally and stirring was continued for 20 hours. Upon completion of the reaction, the mixture was filtered through a Celite pad, the filter cake was washed with EtOAc, and the filtrates were combined and concentrated in vacuo to afford the title compound 17 as a light yellow to cream solid (1.80 g, 94% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 7.12 (d, J = 8.3 Hz, 2H), 6.69 (dd, J = 6.5, 1.9 Hz, 2H), 4.29 (t, J = 8.7 Hz, 2H), 3.93 (dd, J = 8.4, 6.1 Hz, 2H), 3.65 (brs, 2H), 1.55- 1.68 (m, 1H), 1.48 (s, 9H).LCMS analysis: retention time 4.964 min; m/z 249 [M + H]+.

References

[1] Patent: WO2014/26243, 2014, A1. Location in patent: Page/Page column 89
[2] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 133; 134

TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE Suppliers

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916421-36-8, TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATERelated Search:

tert-butyl 3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)piperidine-1-carboxylate tert-Butyl 3-(4-nitrophenyl)azetidine-1-carboxylate tert-butyl 3-(5-(trifluoroMethyl)pyridin-2-yl)azetidine-1-carboxylate tert-butyl 3-(6-aMino-2-MethylpyriMidin-4-yl)piperidine-1-carboxylate tert-butyl 3-(4-benzylpiperazin-1-yl)azetidine-1-carboxylate tert-butyl 3-(4-bromophenyl)azetidine-1-carboxylate tert-butyl 3-(6-nitropyridin-3-yl)azetidine-1-carboxylate TERT-BUTYL 3-(6-CHLOROPYRIDIN-3-YL)AZETIDINE-1-CARBOXYLATE 3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester tert-butyl 3-(6-chloro-2-MethylpyriMidin-4-yl)piperidine-1-carboxylate

  • TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE
  • 4-(1-Boc-3-azetidinyl)aniline
  • 1-Azetidinecarboxylic acid, 3-(4-aminophenyl)-, 1,1-dimethylethyl ester
  • 3- (4-aminophenyl) azacyclobutane-1-carboxylic acid tert butyl ester
  • tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate , tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate
  • 3- (4-aminophenyl) azacyclobutane-1-tert-butyl carboxylate
  • 916421-36-8