4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-

Product Name: 4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-
CAS No.: 459420-09-8
Chemical Name: 4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-
Synonyms: HMPSNE;13MT-3;I3MT-3;I3MT-3 ，S3541;I3MT-3, 10 mM in DMSO;6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one;4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-;6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one[I3MT-3;EA.hy926 cells,Hippo (MST),inhibit,I3MT-3,3MST,HEK293,I3MT3,cell-membrane,COS-7,I-3MT-3,I3MT 3,Inhibitor
CBNumber: CB18233171
Molecular Formula: C17H14N2O2S
Formula Weight: 310.37
MOL File: 459420-09-8.mol

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4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Property

Boiling point:: 514.9±52.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (402.75 mM)
pka: 7.72±0.50(Predicted)
form: Solid
color: Off-white to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0095460
Product name: I3MT-3
Purity: 99.90%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0095460
Product name: I3MT-3
Purity: 99.90%
Packaging: 25mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0095460
Product name: I3MT-3
Purity: 99.90%
Packaging: 100mg
Price: $1950
Updated: 2021/12/16

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4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Chemical Properties,Usage,Production

Uses

I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes.I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST[1].

Biological Activity

I3MT-3 (HMPSNE) is a potent, selective and cell membrane permeable inhibitor of 3-mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM), inactive against other hydrogen sulfide/sulfanilamide sulfur enzymes. I3MT-3 targets a perthiocysteine residue located in the active site of 3MST.

target

IC50: 2.7 μM (3-Mercaptopyruvate sulfurtransferase (3MST))

References

[1] Kenjiro Hanaoka, et al. Discovery and Mechanistic Characterization of Selective Inhibitors of H 2 S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 2017 Jan 12;7:40227 DOI:10.1038/srep40227
[2] Fiona Augsburger, et al. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Biomolecules. 2020 Mar 13;10(3):447. DOI:10.3390/biom10030447

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Preparation Products And Raw materials

Raw materials

Preparation Products

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4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Suppliers

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459420-09-8, 4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-Related Search:

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-

I3MT-3

13MT-3

6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one

6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one[I3MT-3

HMPSNE

EA.hy926 cells,Hippo (MST),inhibit,I3MT-3,3MST,HEK293,I3MT3,cell-membrane,COS-7,I-3MT-3,I3MT 3,Inhibitor

I3MT-3, 10 mM in DMSO

I3MT-3 ，S3541

459420-09-8