ChemicalBook > CAS DataBase List > 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-

9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-

Product Name
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
CAS No.
2342583-66-6
Chemical Name
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
Synonyms
NCC007, 10 mM in DMSO;inhibit,NCC-007,Inhibitor,NCC007,NCC 007,Casein Kinase;9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine;9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
CBNumber
CB18245224
Molecular Formula
C22H28F3N7
Formula Weight
447.5
MOL File
2342583-66-6.mol
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9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Property

Boiling point:
573.5±60.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
form 
Solid
pka
9.02±0.28(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0097017
Product name
NCC007
Purity
99.58%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0097017
Product name
NCC007
Purity
99.58%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0097017
Product name
NCC007
Purity
99.58%
Packaging
25mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0097017
Product name
NCC007
Purity
99.58%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0097017
Product name
NCC007
Purity
99.58%
Packaging
100mg
Price
$750
Updated
2021/12/16
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9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Chemical Properties,Usage,Production

Biological Activity

NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor with IC50 of 1.8 and 3.6 μM, respectively. It can be used for the study of mammalian circadian rhythms.

in vivo

NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.

< /tr>
Animal Model: Adult C57BL/6J background male mice (8 weeks old)
Dosage: 5 , 15 mM
Administration: Infused into the lateral ventricle, constant dark condition
Result: Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM.

target

CKIα

1.8 μM (IC 50 )

CKIδ

3.6 μM (IC 50 )

9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Suppliers

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2342583-66-6, 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-Related Search:


  • 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
  • 9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine
  • inhibit,NCC-007,Inhibitor,NCC007,NCC 007,Casein Kinase
  • NCC007, 10 mM in DMSO
  • 2342583-66-6
  • C22H28F3N7