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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)-

Product Name
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)-
CAS No.
2222114-22-7
Chemical Name
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)-
Synonyms
Thalidomide-Piperazine 5-fluoride;2-(2,6-Dioxo-3-piperidyl)-5-fluoro-6-(1-piperazinyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)-;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione;2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione , Thalidomide-Piperazine 5-fluoride
CBNumber
CB18247233
Molecular Formula
C17H17FN4O4
Formula Weight
360.34
MOL File
2222114-22-7.mol
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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)- Property

Boiling point:
652.2±55.0 °C(Predicted)
Density 
1.475±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, protect from light
form 
Solid
pka
10.59±0.40(Predicted)
color 
Off-white to light green
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Hazard and Precautionary Statements (GHS)

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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)- Chemical Properties,Usage,Production

Uses

Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Hexiang Wang, et al. Degradation of androgen receptor (ar) by conjugation of ar antagonists with e3 ligase ligand and methods of use. WO2021058017A1.

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)- Suppliers

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2222114-22-7, 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)-Related Search:


  • 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)-
  • 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione
  • Thalidomide-Piperazine 5-fluoride
  • 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione , Thalidomide-Piperazine 5-fluoride
  • 2-(2,6-Dioxo-3-piperidyl)-5-fluoro-6-(1-piperazinyl)isoindoline-1,3-dione
  • 2222114-22-7
  • chem-chemical