(S,R,S)-AHPC-PEG6-Azide
- Product Name
- (S,R,S)-AHPC-PEG6-Azide
- CAS No.
- 2086298-71-5
- Chemical Name
- (S,R,S)-AHPC-PEG6-Azide
- Synonyms
- (S,R,S)-AHPC-PEG6-Azide;(2S,4R)-1-((S)-23-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-23-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber
- CB18362273
- Molecular Formula
- C36H55N7O10S
- Formula Weight
- 777.94
- MOL File
- 2086298-71-5.mol
(S,R,S)-AHPC-PEG6-Azide Property
- storage temp.
- 2-8°C
N-Bromosuccinimide Price
- Product number
- 909378
- Product name
- (S,R,S)-AHPC-PEG6-Azide
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $688
- Updated
- 2023/06/20
- Product number
- PTC1640
- Product name
- (S,R,S)-AHPC-PEG6-N3
- Packaging
- 50mg
- Price
- $634.5
- Updated
- 2021/12/16
(S,R,S)-AHPC-PEG6-Azide Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG6-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
(S,R,S)-AHPC-PEG6-Azide Preparation Products And Raw materials
Raw materials
Preparation Products
(S,R,S)-AHPC-PEG6-Azide Suppliers
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View Lastest Price from (S,R,S)-AHPC-PEG6-Azide manufacturers
- Product
- (S,R,S)-AHPC-PEG6-Azide 2086298-71-5
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01