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Etodesnitazene

Product Name
Etodesnitazene
CAS No.
14030-76-3
Chemical Name
Etodesnitazene
Synonyms
Etodesnitazene;{2-[2-(4-ethoxy-benzyl)-;Etazo/Ne;Etazene, Desnitroetonitazene;Desnitroetonitazene (Etazene);{2-[2-(4-ethoxy-benzyl)-benzoimidazol-1-yl]-ethyl}-di;1-(2-Diaethylamino-aethyl)-2-(4-aethoxy-benzyl)-benzimidazol;Etodesnitazene(Desnitroetonitazene, Etazen, Etazene, Etazone);{2-[2-(4-ethoxy-benzyl)-benzoimidazol-1-yl]-ethyl}-diethyl-amine;1H-Benzimidazele-1-ethanamine,2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-
CBNumber
CB18382895
Molecular Formula
C22H29N3O
Formula Weight
351.49
MOL File
14030-76-3.mol
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Etodesnitazene Property

Melting point:
65-66 °C(Solv: ethyl ether (60-29-7))
Boiling point:
521.5±40.0 °C(Predicted)
Density 
1.06±0.1 g/cm3(Predicted)
solubility 
soluble in water and methanol and partially soluble in dichloromethane.
pka
10.02±0.25(Predicted)
InChI
InChI=1S/C22H29N3O/c1-4-24(5-2)15-16-25-21-10-8-7-9-20(21)23-22(25)17-18-11-13-19(14-12-18)26-6-3/h7-14H,4-6,15-17H2,1-3H3
InChIKey
BMLPNUNXHUGDOI-UHFFFAOYSA-N
SMILES
C1(CC2=CC=C(OCC)C=C2)N(CCN(CC)CC)C2=CC=CC=C2N=1
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Hazard and Precautionary Statements (GHS)

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Etodesnitazene Chemical Properties,Usage,Production

Description

Etodesnitazene is a new synthetic opioid bearing structural resemblance to etonitazene, a synthetic opioid that is nationally and internationally controlled. Etodesnitazene is dissimilar in structure to synthetic opioids typically encountered in forensic casework (e.g., fentanyl, heroin); however, several analogues of this series (known as “nitazenes”) have recently emerged in several countries around the world. In vitro pharmacological data show that etodesnitazene is an active opioid agonist which is approximately four times less potent than fentanyl (a common phenomenon for analogues missing the 5-nitro group) but approximately six times more potent than morphine. Etodesnitazene was first reported by NPS Discovery in February 2021 following initial detection in a toxicology case.

Chemical Properties

Etazene dihydrochloride in seized material has been reported as a grey crystalline powder or a light-yellow powder. Etazene citrate sold as a reference material has been described as a crystalline solid.

History

Etodesnitazene is a benzimidazole derived opioid analgesic drug, which was originally developed in the late 1950s alongside etonitazene and a range of related derivatives.

Uses

Etodesnitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

Regulatory Status

Etodesnitazene is classified as a novel opioid of the benzimidazole sub-class and is structurally dissimilar from fentanyl.Novel opioids have been reported to cause psychoactive effects similar to heroin, fentanyl, and other opioids. Novel opioids have also caused adverse events, including death, as described in the literature.Structurally similar compounds include etonitazene, metonitazene, and isotonitazene. Etonitazene and its analogue synthetic opioids were first synthesized and reported in the literature in the 1950s.Data suggest that this group of nitrocontaining analogues can have potency similar to or greater than fentanyl.Recent in vitro data suggest that etodesnitazene is less potent than fentanyl. Etodesnitazene is not explicitly scheduled in the United States; however, etonitazene and isotonitazene are Schedule I substances.

References

1. Grigoryev A, Kavanagh P, Dowling G, Rodin I. Tentative identification of etazene (etodesnitazene) metabolites in rat serum and urine by gas chromatography–mass spectrometry and accurate mass liquid chromatography–mass spectrometry. J Anal Toxicol. 2022 (doi: 10.1093/jat/bkac001).
2. NPS discovery: Etodesnitazene – New synthetic opioid identified during forensic death investigations in the United States and Canada. Willow Grove (PA): Center for Forensic Science Research and Education; 2021.
3. Grass Valley (CA): Exploring a Not Very Known Opioid Etodesnitazene. Erowid Center; 2022 (https://erowid.org/experiences/exp_front.shtml, accessed 20 July 2022).
4. https://cdn.who.int/media/docs/default-source/controlled-substances/45th-ecdd/etazene_draft.pdf?sfvrsn=cc970e16_1
5. https://www.drugsandalcohol.ie/35343/

Etodesnitazene Preparation Products And Raw materials

Raw materials

Preparation Products

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Etodesnitazene Suppliers

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View Lastest Price from Etodesnitazene manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
1H-Benzimidazele-1-ethanamine,2- [(4-ethoxyphenyl)methyl]-N,N- diethyl- 14030-76-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-11
ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
Product
Etodesnitazene 14030-76-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5ton/month
Release date
2023-12-09
Shandong Huisheng Import & Export Co., Ltd.
Product
Etodesnitazene 14030-76-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%~99%
Supply Ability
20 T each week
Release date
2023-10-18

14030-76-3, EtodesnitazeneRelated Search:


  • 1H-Benzimidazole-1-ethanamine, 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-
  • Desnitroetonitazene (Etazene)
  • Etazo/Ne
  • {2-[2-(4-ethoxy-benzyl)-benzoimidazol-1-yl]-ethyl}-diethyl-amine
  • {2-[2-(4-ethoxy-benzyl)-
  • Etodesnitazene
  • Etazene, Desnitroetonitazene
  • Etodesnitazene(Desnitroetonitazene, Etazen, Etazene, Etazone)
  • 1H-Benzimidazele-1-ethanamine,2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-
  • 1-(2-Diaethylamino-aethyl)-2-(4-aethoxy-benzyl)-benzimidazol
  • {2-[2-(4-ethoxy-benzyl)-benzoimidazol-1-yl]-ethyl}-di
  • 14030-76-3
  • 14030-76-3