ChemicalBook > CAS DataBase List > 2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro-
2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro-
- Product Name
- 2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro-
- CAS No.
- 2244881-69-2
- Chemical Name
- 2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro-
- Synonyms
- STING-IN-3;C-171 STING inhibitor;STING-IN-3, 10 mM in DMSO;N-(4-Hexylphenyl)-5-nitro-2-furancarboxamide;N-(4-hexylphenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro-;genes,inhibit,ERIS,TMEM173,mmSTING,Inhibitor,Stimulator of Interferon Genes,STING,MPYS,MITA,stimulator,hsSTING,STINGIN3,interferon,STING IN 3
- CBNumber
- CB18396720
- Molecular Formula
- C17H20N2O4
- Formula Weight
- 316.35
- MOL File
- 2244881-69-2.mol
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2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro- Property
- Boiling point:
- 388.5±37.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml,DMSO: 25 mg/ml
- form
- A crystalline solid
- pka
- 11.89±0.70(Predicted)
- color
- Light yellow to green yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 30159
- Product name
- C-171
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30159
- Product name
- C-171
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $132
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30159
- Product name
- C-171
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $220
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30159
- Product name
- C-171
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $412
- Updated
- 2024/03/01
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2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro- Chemical Properties,Usage,Production
Description
C-171 is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1. It selectively reduces human and mouse STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 μM.
Uses
STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING[1].
References
[1] Haag SM, et, al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. DOI:10.1038/s41586-018-0287-8
2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro- Preparation Products And Raw materials
Raw materials
Preparation Products
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2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro- Suppliers
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