7-HYDROXY-NAPHTHALENE-2-CARBONITRILE
- Product Name
- 7-HYDROXY-NAPHTHALENE-2-CARBONITRILE
- CAS No.
- 130200-58-7
- Chemical Name
- 7-HYDROXY-NAPHTHALENE-2-CARBONITRILE
- Synonyms
- EOS-62010;7-Cyano-2-naphthol;Naproxen Impurity 25;7-Hydroxy-2-naphthalenecarbonitrile;7-HYDROXY-NAPHTHALENE-2-CARBONITRILE;2-Naphthalenecarbonitrile, 7-hydroxy-;7-hydroxy-2-naphthonitrile130200-58-7;Phenol,2,2'-[1,4-ethanediylbis(iminomethylene)]bis-;Carbamicacid,N-[2-[2-(2-bromoethoxy)ethoxy]ethyl]-,1,6-dimethylethylester;Butyl Parahydroxybenzoate Impurity 3 (Butyl Parahydroxybenzoate EP Impurity C)
- CBNumber
- CB1839889
- Molecular Formula
- C11H7NO
- Formula Weight
- 169.18
- MOL File
- 130200-58-7.mol
7-HYDROXY-NAPHTHALENE-2-CARBONITRILE Property
- Melting point:
- 186.5 °C
- Boiling point:
- 383.1±15.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.99±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 296602
- Product name
- 7-Hydroxy-2-naphthonitrile
- Packaging
- 250.00mg
- Price
- $67
- Updated
- 2026/05/19
- Product number
- 296602
- Product name
- 7-Hydroxy-2-naphthonitrile
- Packaging
- 1.00g
- Price
- $200
- Updated
- 2026/05/19
- Product number
- 296602
- Product name
- 7-Hydroxy-2-naphthonitrile
- Packaging
- 5.00g
- Price
- $866
- Updated
- 2026/05/19
- Product number
- H55194
- Product name
- 7-Hydroxy-2-naphthonitrile
- Purity
- 98%
- Packaging
- 100mg
- Price
- $53
- Updated
- 2026/05/06
- Product number
- H55194
- Product name
- 7-Hydroxy-2-naphthonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $70
- Updated
- 2026/05/06
7-HYDROXY-NAPHTHALENE-2-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
90381-43-4
130200-58-7
General procedure for the synthesis of 7-hydroxy-2-naphthalenecarbonitrile from 7-methoxy-2-naphthalenecarbonitrile: A solution of boron tribromide (840 μL, 8.8 mmol) in dichloromethane (4 mL) was added slowly and dropwise to a solution of 7-methoxy-2-naphthalenecarbonitrile (646 mg, 3.53 mmol) in dichloromethane (6 mL) under nitrogen protection. The reaction mixture was stirred at room temperature for 30 hours. Upon completion of the reaction, the reaction was quenched by the slow addition of deionized water (~5 mL). The pH of the reaction mixture was adjusted to 7 with saturated sodium carbonate solution and subsequently extracted with dichloromethane. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a mixture of dichloromethane and methanol (gradient elution: 1% dichloromethane solution in methanol to 5% dichloromethane solution in methanol) to afford 7-hydroxy-2-naphthalenecarbonitrile as a white solid (477 mg, 80% yield). The result of high resolution mass spectrometry (EI) analysis: the calculated value of C11H7NO was 169.0528 and the measured value was 169.0527.
References
[1] Helvetica Chimica Acta, 1997, vol. 80, # 3, p. 892 - 896
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1156 - 1160
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 22, p. 7434 - 7445
[4] Patent: US2003/236270, 2003, A1. Location in patent: Page 39
[5] Journal of the American Chemical Society, 1994, vol. 116, # 23, p. 10593 - 10600
7-HYDROXY-NAPHTHALENE-2-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-HYDROXY-NAPHTHALENE-2-CARBONITRILE manufacturers
- Product
- 7-HYDROXY-NAPHTHALENE-2-CARBONITRILE 130200-58-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02