1H-PYRAZOL-4-YLAMINE

Form

Product Name: 1H-PYRAZOL-4-YLAMINE
CAS No.: 28466-26-4
Chemical Name: 1H-PYRAZOL-4-YLAMINE
Synonyms: 1H-Pyrazol-4-amine;4-AMINOPYRAZOLE;4-AMINO-1H-PYRAZOLE;AKOS PAO-0001;H-PYRAZOL-4-YLAMINE;1H-Pyrazole-4-amine;4-Aminopyrazole 95%;1H-PYRAZOL-4-YLAMINE;1H-Pyrazol-4-amine (9CI, ACI)
CBNumber: CB1840324
Molecular Formula: C3H5N3
Formula Weight: 83.09
MOL File: 28466-26-4.mol

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1H-PYRAZOL-4-YLAMINE Property

Melting point:: 75-77°C
Boiling point:: 142.17°C (rough estimate)
Density: 1.0248 (rough estimate)
refractive index: 1.5060 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form: powder to crystal
pka: 17.70±0.50(Predicted)
color: White to Brown to Dark purple
Sensitive: Hygroscopic
InChI: InChI=1S/C3H5N3/c4-3-1-5-6-2-3/h1-2H,4H2,(H,5,6)
InChIKey: AXINVSXSGNSVLV-UHFFFAOYSA-N
SMILES: N1C=C(N)C=N1
CAS DataBase Reference: 28466-26-4
NIST Chemistry Reference: 4-NH2-pyrazole(28466-26-4)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
RTECS: UQ4993000
HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 700940
Product name: 4-Aminopyrazole
Purity: 95%
Packaging: 1g
Price: $130
Updated: 2025/07/31

TCI Chemical

Product number: P2523
Product name: 1H-Pyrazol-4-amine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $77
Updated: 2025/07/31

TRC

Product number: A628905
Product name: 4-Amino-1H-pyrazole
Packaging: 1g
Price: $120
Updated: 2021/12/16

TRC

Product number: A628905
Product name: 4-Amino-1H-pyrazole
Packaging: 5g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA55418
Product name: 4-Amino-1H-pyrazole
Packaging: 10g
Price: $350
Updated: 2021/12/16

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1H-PYRAZOL-4-YLAMINE Chemical Properties,Usage,Production

Form

powder

Chemical Properties

It is white to brownish-purple solid under normal temperature and pressure, with certain alkalinity, and can form salts with various acids.

Uses

4-Aminopyrazole, is a versatile building block for the preparation of pharmaceutical and biologically active compounds. 4-Amino-1H-pyrazole, has also shown to have anticonvulsant activity, and thus can be used in the treatment of epileptic seizures.

Synthesis

2075-46-9

28466-26-4

4-Nitropyrazole (1.13 g, 10 mmol) was dissolved in methanol (10 mL) under hydrogen (1 atm) atmosphere and 10% Pd-C catalyst (0.1 g) was added. The reaction mixture was stirred at 25 °C for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-aminopyrazole (860 mg, yield: 100%), which could be used in subsequent reactions without further purification.

References

[1] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0252; 0253
[2] ChemMedChem, 2016, p. 1695 - 1699
[3] Patent: CN105418616, 2016, A. Location in patent: Paragraph 0118; 0119
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 3, p. 395 - 399
[5] Patent: WO2017/178510, 2017, A1. Location in patent: Page/Page column 297

1H-PYRAZOL-4-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-PYRAZOL-4-YLAMINE Suppliers

China 154 Germany 1 India 10 Japan 1 United Kingdom 5 United States 16 Global 187

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
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J & K SCIENTIFIC LTD.

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Pure Chemistry Scientific Inc.

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Adamas Reagent, Ltd.

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View Lastest Price from 1H-PYRAZOL-4-YLAMINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1H-PYRAZOL-4-YLAMINE 28466-26-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Career Henan Chemical Co

Product: 1H-PYRAZOL-4-YLAMINE 28466-26-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-20

28466-26-4, 1H-PYRAZOL-4-YLAMINERelated Search:

Mordant Red 7 1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE ACID ORANGE 63 ACID YELLOW 54 ACID RED 183 ACID YELLOW 40 ACID ORANGE 74 ACID YELLOW 11 CIBACRON BRILLIANT YELLOW 3G-P Mordant Red 19 5-CHLORO-1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE 3-Methyl-4-nitropyrazole 3,5-Dimethyl-4-nitro-1H-pyrazole 1-ISOPROPYL-1H-PYRAZOL-5-AMINE 3-Aminopyrazole-4-carboxylic acid 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 1,5-DIMETHYL-1 H-PYRAZOL-3-YLAMINE 5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

4-Aminopyrazole 95%

1H-Pyrazol-4-amine

AKOS PAO-0001

1H-PYRAZOL-4-YLAMINE

4-AMINOPYRAZOLE

4-AMINO-1H-PYRAZOLE

1H-Pyrazole-4-amine

H-PYRAZOL-4-YLAMINE

1H-Pyrazol-4-amine (9CI, ACI)

28466-26-4

Pyrazole series

API intermediates