Ipronidazole
- Product Name
- Ipronidazole
- CAS No.
- 14885-29-1
- Chemical Name
- Ipronidazole
- Synonyms
- Ipropan;Ipropran;Ro7-1554;Ro 07-1554;NSC-109212;C14370700 Ipronidazole;Ipronidazole in Methanol;Ipronidazole Solution, 100ppm;Ipronidazole 100 μg/ml Methanol;1-Methyl-2-(1-Methylethyl)-5-nitro-
- CBNumber
- CB1875030
- Molecular Formula
- C7H11N3O2
- Formula Weight
- 169.18
- MOL File
- 14885-29-1.mol
Ipronidazole Property
- Melting point:
- 60°
- Boiling point:
- 298.47°C (rough estimate)
- Density
- 1.2509 (rough estimate)
- refractive index
- 1.5950 (estimate)
- solubility
- DMF: 14 mg/mL; DMSO: 11 mg/mL; Ethanol: 12 mg/mL; PBS (pH 7.2): 0.16 mg/mL
- pka
- 2.55±0.25(Predicted)
- Water Solubility
- 9.4g/L(20 ºC)
- BRN
- 744577
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 32173
- Product name
- Ipronidazole
- Purity
- VETRANAL , analytical standard
- Packaging
- 10mg
- Price
- $676
- Updated
- 2024/03/01
- Product number
- I747000
- Product name
- Ipronidazole
- Packaging
- 100mg
- Price
- $840
- Updated
- 2021/12/16
- Product number
- I747000
- Product name
- Ipronidazole
- Packaging
- 50mg
- Price
- $435
- Updated
- 2021/12/16
- Product number
- API0008016
- Product name
- IPRONIDAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- API0008016
- Product name
- IPRONIDAZOLE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $739.2
- Updated
- 2021/12/16
Ipronidazole Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Originator
Ipropran,Roche,W. Germany,1981
Uses
Ipronidazole may be used as a reference standard in the determination of ipronidazole in tissue samples using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC) and thermospray tandem mass spectrometry (HPLC-MS/MS).
Uses
An antihistomonal agent. Antiprotozoal (Histomonas).
Definition
ChEBI: Ipronidazole is a C-nitro compound and a member of imidazoles.
Manufacturing Process
2-Isopropyl-4 (or 5-nitroimidazole) (31 g = 0.2 mol), dioxane (70 g) and
dimethylsulfate (28 g = 0.22 mol) were heated on a steam bath under reflux
for 45 minutes. The solvent was removed in vacuo on a steam bath, the
residue dissolved in 20 ml of water and the product precipitated by the
gradual addition of 80 g of 25% sodium hydroxide solution at 0°C. A small
additional amount was obtained by extraction of the mother liquor with
methylene chloride. The product melted at 60°C.
The product was purified as follows. 60 g of product was dissolved in 3N
aqueous hydrochloric acid, the solution was treated with charcoal and filtered.
The filtrate was neutralized by the gradual addition of aqueous concentrated
ammonia at 0°C to 5°C under stirring whereupon the product precipitated in
white plates as the neutralization proceeded. The precipitate was filtered by
suction, washed on the filter with 50 ml of ice cold water and dried at room
temperature, MP 60°C.
The hydrochloride salt was formed by reacting the product, dissolved in
isopropanol, with 25% ethanolic hydrochloric acid, whereupon the salt
precipitated and was isolated. It has a melting point of 177°C to 182°C (dec).
Similarly, the bisulfate salt was formed using 96% sulfuric acid. It has a MP of
151.5°C to 152.5°C.
brand name
Ipropran [Veterinary] (Hoffmann-LaRoche).
Therapeutic Function
Antiprotozoal
General Description
Ipronidazole is a veterinary drug, which is widely used in controlling histomoniasis in turkeys.
Ipronidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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