p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride
- Product Name
- p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride
- CAS No.
- 1215-83-4
- Chemical Name
- p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride
- Synonyms
- Silom;Petoxil;Silomat;Silonist;Pertoxil;1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol hydrochloride;1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol hydrochloride;1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-butan-2-ol hydrochloride;p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride
- CBNumber
- CB1887547
- Molecular Formula
- C14H23Cl2NO
- Formula Weight
- 292.24452
- MOL File
- 1215-83-4.mol
p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride Property
- Melting point:
- 169-170°
Safety
- Toxicity
- LD50 in mice (mg/kg): 600 orally; 130 i.p. (Engelhorn)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C583600
- Product name
- ClobutinolHydrochloride
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- C583600
- Product name
- ClobutinolHydrochloride
- Packaging
- 50mg
- Price
- $535
- Updated
- 2021/12/16
- Product number
- API0010390
- Product name
- CLOBUTINOL HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $280.35
- Updated
- 2021/12/16
p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride Chemical Properties,Usage,Production
Originator
Silomat,Boehringer Ingelheim,Switz.,1960
Uses
Clobutinol Hydrochloride is a non-narcotic antitussive drug useful for treatment of acute respiratory diseases.
Definition
ChEBI: Clobutinol hydrochloride is a member of benzenes and an organic amino compound.
Manufacturing Process
A solution of 0.2 mol (33 g) of 3-methyl-4-dimethylamino-butanone-(2)
[produced according to Mannich, Arch. Pharm., vol. 265, page 589 (1927)] in
50 cc absolute ether was added dropwise, while stirring and cooling with ice,
to a Grignard solution of 0.4 mol p-chlorobenzylmagnesium-chloride which
was produced from 64.5 g p-chlorobenzyl-chloride and 9.8 g magnesium in
200 cc absolute ether. The reaction product was heated for an additional onehalf hour under reflux to bring the reaction to completion, and thereafter the
reaction mixture was decomposed into an ether phase and an aqueous phase
with about 50 cc concentrated hydrochloric acid and about 200 g ice. The
ether phase was discarded and the aqueous phase was adjusted to an alkaline
pH with ammonia and then thoroughly extracted with ether. After
concentrating the united, dried ether extract solutions, the oily residue was
fractionally distilled. The reaction product was obtained in the form of a
colorless oil having a boiling point of 179° to 181°C. The yield was 48.5 g
corresponding to 95% of theory.
The hydrochloride addition salt of the above reaction product was prepared in
customary fashion, that is, by reaction with hydrochloric acid, followed by
fractional crystallization from a mixture of alcohol and ether. The two possible
racemic forms were obtained thereby. The difficultly soluble racemate had a
melting point of 169° to 170°C and the more readily soluble racemate had a
boiling point of 145° to 148°C.
Therapeutic Function
Antitussive
p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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