ChemicalBook > CAS DataBase List > 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

Product Name
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
CAS No.
77017-20-0
Chemical Name
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
Synonyms
BNKY015-BD01;Desonide Impurity M1;Budesonide Impurity 33;Budesonide Impurity 12;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
CBNumber
CB1894903
Molecular Formula
C23H28O6
Formula Weight
400.46482
MOL File
77017-20-0.mol
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16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Property

Melting point:
213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
Boiling point:
576.7±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
solubility 
soluble in Acetone, Dichloromethane
pka
11.92±0.70(Predicted)
Water Solubility 
38.72mg/L at 25℃
LogP
2.26 at 25℃
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
67632
Product name
(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
Packaging
10mg
Price
$640
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006413
Product name
16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE
Purity
95.00%
Packaging
10MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006413
Product name
16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE
Purity
95.00%
Packaging
100MG
Price
$1871.1
Updated
2021/12/16
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16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties,Usage,Production

Uses

Intermediate in the preparation of antiinflammatory compounds.

Synthesis

2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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77017-20-0, 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetateRelated Search:

Budesonide Impurity 30 Prednisone 17, 21-Diacetate 11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione Budesonide Impurity 11 Budesonide Impurity 7 21-Dehydro Budesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) (11β,16α)-21-(Acetyloxy)-11,16,17-trihydroxypregna-1,4,14-triene-3,20-dione 11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate GOJZZYSAJXCRGI-KXGXINSVSA-N 16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Budesonide iMpurity Budesonide Impurity (1, 4-Androstadien-11-beta-16-alfa-diol-3, 17-dione) Budesonide Impurity 6 21-Dehydro-16α-hydroxy Prednisolone 2,4,6-tripropyl-1,3,5-trioxane Budesonide (r)-budesonide

  • 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
  • 16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
  • 16-alpha,17-alpha-dihydroxy-3,20-dioxopregna- 1,4,9(11)-trien-21-yl acetate
  • Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate
  • 21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione
  • (16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
  • BNKY015-BD01
  • Budesonide Impurity 12
  • Pregna-1,4,9(11)-triene-3,20-dione, 21-(acetyloxy)-16,17-dihydroxy-, (16α)-
  • Pregna-1,4,9(11)-triene-3,20-dione,21-(acetyloxy)-16,17-dihydroxy-, (16a)- (9CI)
  • Budesonide Impurity 33
  • 16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
  • Desonide Impurity M1
  • "(16a)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione"
  • 2-((8S,10S,13S,14S,16R,17S)-16,17-Dihydroxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate
  • 2-[(8S,10S,13S,14S,16R,17S)-16,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]acetate
  • 77017-20-0
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids