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glucose 1-(dihydrogen phosphate)

Product Name
glucose 1-(dihydrogen phosphate)
CAS No.
59-56-3
Chemical Name
glucose 1-(dihydrogen phosphate)
Synonyms
GLC-1-P;glucose-1P;Glucose-1-phosphate;alpha-D-glucose-1-P;a-Glucose-1-phosphate;Glucose monophosphate.;α-D-glucose1-phosphate;alpha-glucose-1-phosphate;D-glucose-alpha-1-phosphate;HXXFSFRBOHSIMQ-VFUOTHLCSA-N
CBNumber
CB1906439
Molecular Formula
C6H13O9P
Formula Weight
260.13
MOL File
59-56-3.mol
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glucose 1-(dihydrogen phosphate) Property

Boiling point:
603.0±65.0 °C(Predicted)
Density 
1.90±0.1 g/cm3(Predicted)
solubility 
Soluble (water), slightly soluble (ethanol)
form 
Solid
pka
pKa: 6.504(25°C)
color 
White to off-white
optical activity
Alpha type +120
EPA Substance Registry System
.alpha.-D-Glucopyranose, 1-(dihydrogen phosphate) (59-56-3)
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Safety

RIDADR 
1759
HazardClass 
8
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
167838
Product name
Glucose-1-Phosphate
Packaging
100Tests
Price
$772
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CRB0004385
Product name
ALPHA-GLUCOSE-1-PHOSPHATE
Purity
95.00%
Packaging
5MG
Price
$505.3
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
824
Product name
α-D-1-13C-Glucopyranosyl1-phosphate
Packaging
0.1g
Price
$550
Updated
2021/12/16
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glucose 1-(dihydrogen phosphate) Chemical Properties,Usage,Production

Uses

α-D-Glucose-1-phosphate is an important intermediate in sugar metabolism, functioning as a glycosyl donor in glycosyl transfer reactions and participating in glycogen synthesis and degradation through the action of phosphorylases[1].

Definition

ChEBI: A D-glucopyranose 1-phosphate in which the anomeric centre has alpha-configuration.

IC 50

Human Endogenous Metabolite

Purification Methods

Two litres of a 5% aqueous solution of the phosphate are purified by adjusting the pH to 3.5 with glacial acetic acid (+ 3g of charcoal) and filtering. An equal volume of EtOH is added, the pH is adjusted to 8.0 (glass electrode) and the solution is stored at 3o overnight. The precipitate is filtered off, dissolved in 1.2L of distilled water, filtered and an equal volume of EtOH is added. After standing at 0o overnight, the crystals are collected at the centrifuge and washed with 95% EtOH, then absolute EtOH, ethanol/diethyl ether (1:1), and diethyl ether. [Sutherland & Wosilait, J Biol Chem 218 459 1956.] Its barium salt can be crystallised from water and EtOH. Heavy metal impurities are removed by passage of an aqueous solution (ca 1%) through an Amberlite IR-120 column (in the appropriate H+, Na+ or K+ forms). Di-K salt crystallises as a dihydrate from EtOH. [see McGready Biochemical Preparations 4 63 1955.] [Beilstein 17/8 V 247.]

References

[1] Nihira T, et al. 2-O-α-D-glucosylglycerol phosphorylase from Bacillus selenitireducens MLS10 possessing hydrolytic activity on β-D-glucose 1-phosphate. PLoS One. 2014 Jan 22;9(1):e86548. DOI:10.1371/journal.pone.0086548

glucose 1-(dihydrogen phosphate) Preparation Products And Raw materials

Raw materials

Preparation Products

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