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Cefacetrile sodium

Product Name
Cefacetrile sodium
CAS No.
23239-41-0
Chemical Name
Cefacetrile sodium
Synonyms
C12691;BA-36278;Celospor;BA-36278A;Ciba-36278-Ba;CEFACETRILE SODIUM;Cephacetrile sodium;Cefacetrile sodium (JAN);Cefacetrile sodium USP/EP/BP;sodium (6R-trans)-3-(acetoxymethyl)-7-(cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CBNumber
CB1920963
Molecular Formula
C13H12N3NaO6S
Formula Weight
361.30565
MOL File
23239-41-0.mol
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Cefacetrile sodium Property

Melting point:
>167°C (dec.)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
DMF (Slightly), DMSO (Slightly)
form 
Solid
color 
Pale Beige
Stability:
Hygroscopic
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Safety

Toxicity
LD50 in mice (mg/kg): 4500 ± 540 i.v.; 9100 ± 1500 s.c. (Kradolfer)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C231505
Product name
CefacetrileSodium
Packaging
5mg
Price
$145
Updated
2021/12/16
TRC
Product number
C231505
Product name
CefacetrileSodium
Packaging
50mg
Price
$1165
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001880
Product name
CEFACETRILE SODIUM
Purity
95.00%
Packaging
5MG
Price
$502.9
Updated
2021/12/16
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Cefacetrile sodium Chemical Properties,Usage,Production

Description

Cephacetrile was synthesized by Ciba-Geigy in 1970. It shows almost the same activity against gram-negative bacteria as cephalothin, but it has a higher activity against β-lactamaseproducing Escherichia coli. Like cephalothin, it is metabolized partially by deacetylation in vivo. Cephacetrile has been used to treat sepsis and abdominal and respiratory tract infections caused by Staphylococcus, Streptococcus, Escherichia coli, and Klebsiella pneumoniae, but it is gradually being replaced clinically by the newer and more active cephalosporins.

Originator

Celospor,Ciba Geigy,Switz.,1969

Uses

Cefacetrile Sodium is a cephalosporin antibiotic. Antibacterial.

Definition

ChEBI: Cefacetrile sodium is an organic molecular entity.

Manufacturing Process

13.6 g (0.05 mol) of 7-aminocephalosporanic acid are taken up in a mixture of 150 ml of methylene chloride and 19.5 ml of tributylamine (0.12 mol) and at 0°C a solution of 8.4 g of cyanoacetylchloride (0.07 mol) in 100 ml of methylene chloride is stirred in. The bath is then stirred for ? hour at 0°C and for ? hour at 20°C, the reaction solution is evaporated under vacuum and the residue taken up in 10% aqueous dipotassium hydrogenphosphate solution. This aqueous phase is washed with ethyl acetate, acidified to pH 2.0 with concentrated hydrochloric acid and extracted with ethyl acetate.
After having been dried over sodium sulfate and evaporated under vacuum, this extract gives as a solid residue 14.7 g of crude 7-cyanoacetylamino-cephalosporanic acid which is purified by chromatography on 30 times its own weight of silica gel. The fractions eluted with chloroform plus acetone (7:3) furnish a product which crystallizes from acetone plus ether in the form of needles melting at 168° to 170°C with decomposition.
5.10 g (15 mmol) of 7-cyanoacetyl-aminocephalosporanic acid are suspended in 102 ml of distilled water and converted into the sodium salt by stirring in dropwise 15 ml of N sodium hydroxide solution.

Therapeutic Function

Antibiotic

Cefacetrile sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Cefacetrile sodium Suppliers

Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9649
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58
Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9640
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58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81145920 13259709322
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10009
Advantage
58

23239-41-0, Cefacetrile sodiumRelated Search:


  • sodium (6R-trans)-3-(acetoxymethyl)-7-(cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Cefacetrile sodium (JAN)
  • CEFACETRILE SODIUM
  • Cephacetrile sodium
  • Sodium (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • BA-36278
  • BA-36278A
  • Celospor
  • Ciba-36278-Ba
  • C12691
  • Cefacetrile sodium USP/EP/BP
  • 23239-41-0
  • C13H12N3NaO6S
  • C13H12N3O6SNa