Cefacetrile sodium
- Product Name
- Cefacetrile sodium
- CAS No.
- 23239-41-0
- Chemical Name
- Cefacetrile sodium
- Synonyms
- C12691;BA-36278;Celospor;BA-36278A;Ciba-36278-Ba;CEFACETRILE SODIUM;Cephacetrile sodium;Cefacetrile sodium (JAN);Cefacetrile sodium USP/EP/BP;sodium (6R-trans)-3-(acetoxymethyl)-7-(cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- CBNumber
- CB1920963
- Molecular Formula
- C13H12N3NaO6S
- Formula Weight
- 361.30565
- MOL File
- 23239-41-0.mol
Cefacetrile sodium Property
- Melting point:
- >167°C (dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMF (Slightly), DMSO (Slightly)
- form
- Solid
- color
- Pale Beige
- Stability:
- Hygroscopic
Safety
- Toxicity
- LD50 in mice (mg/kg): 4500 ± 540 i.v.; 9100 ± 1500 s.c. (Kradolfer)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C231505
- Product name
- CefacetrileSodium
- Packaging
- 5mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- C231505
- Product name
- CefacetrileSodium
- Packaging
- 50mg
- Price
- $1165
- Updated
- 2021/12/16
- Product number
- API0001880
- Product name
- CEFACETRILE SODIUM
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.9
- Updated
- 2021/12/16
Cefacetrile sodium Chemical Properties,Usage,Production
Description
Cephacetrile was synthesized by Ciba-Geigy in 1970. It shows almost the same activity against gram-negative bacteria as cephalothin, but it has a higher activity against β-lactamaseproducing Escherichia coli. Like cephalothin, it is metabolized partially by deacetylation in vivo. Cephacetrile has been used to treat sepsis and abdominal and respiratory tract infections caused by Staphylococcus, Streptococcus, Escherichia coli, and Klebsiella pneumoniae, but it is gradually being replaced clinically by the newer and more active cephalosporins.
Originator
Celospor,Ciba Geigy,Switz.,1969
Uses
Cefacetrile Sodium is a cephalosporin antibiotic. Antibacterial.
Definition
ChEBI: Cefacetrile sodium is an organic molecular entity.
Manufacturing Process
13.6 g (0.05 mol) of 7-aminocephalosporanic acid are taken up in a mixture
of 150 ml of methylene chloride and 19.5 ml of tributylamine (0.12 mol) and
at 0°C a solution of 8.4 g of cyanoacetylchloride (0.07 mol) in 100 ml of
methylene chloride is stirred in. The bath is then stirred for ? hour at 0°C
and for ? hour at 20°C, the reaction solution is evaporated under vacuum
and the residue taken up in 10% aqueous dipotassium hydrogenphosphate
solution. This aqueous phase is washed with ethyl acetate, acidified to pH 2.0
with concentrated hydrochloric acid and extracted with ethyl acetate.
After having been dried over sodium sulfate and evaporated under vacuum,
this extract gives as a solid residue 14.7 g of crude 7-cyanoacetylamino-cephalosporanic acid which is purified by chromatography on 30 times its own
weight of silica gel. The fractions eluted with chloroform plus acetone (7:3)
furnish a product which crystallizes from acetone plus ether in the form of
needles melting at 168° to 170°C with decomposition.
5.10 g (15 mmol) of 7-cyanoacetyl-aminocephalosporanic acid are suspended in 102 ml of distilled water and converted into the sodium salt by stirring in
dropwise 15 ml of N sodium hydroxide solution.
Therapeutic Function
Antibiotic
Cefacetrile sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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