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bucloxic acid

Product Name
bucloxic acid
CAS No.
32808-51-8
Chemical Name
bucloxic acid
Synonyms
Esfar;804CB;Bucloxic;bucloxic acid;Acide bucloxique;32808-53-0 (Calcium salt);Acide bucloxique [inn-french];32808-52-9 (Hydrochloride-salt);3-Chloro-4-cyclohexyl-γ-oxobenzenebutyric acid;3-(3-chloro-4-cyclohexylbenzoyl)propionic acid
CBNumber
CB1924022
Molecular Formula
C16H19ClO3
Formula Weight
294.776
MOL File
32808-51-8.mol
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bucloxic acid Property

Melting point:
163°
Boiling point:
408.08°C (rough estimate)
Density 
1.1280 (rough estimate)
refractive index 
1.4585 (estimate)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
4.43±0.17(Predicted)
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Safety

Toxicity
LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0010869
Product name
BUCLOXIC ACID
Purity
95.00%
Packaging
5MG
Price
$503.62
Updated
2021/12/16
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bucloxic acid Chemical Properties,Usage,Production

Originator

Esfar,Clin Midy,France,1974

Definition

ChEBI: Bucloxic acid is an aromatic ketone.

Manufacturing Process

Phenylcyclohexane and succinic acid (Bernstein Acid) anhydride are reacted in the presence of AlCl3to give 4-(4'-cyclohexylphenyl)-4-keto-n-butyric acid.
177 grams of anhydrous aluminum chloride are introduced into a 3-necked 1 liter flask. A hot solution of 144 grams of 4-(4'-cyclohexylphenyl)-4-keto-nbutyric acid in 330 ml of methylene chloride is added slowly from a dropping funnel. Slight reflux is observed during this addition. 33.2ml of liquefied chlorine are then introduced slowly, drop by drop. This addition requires 5 hours. The solution is then poured on to 1 kg of ice containing 100 ml of concentrated hydrochloric acid. The aqueous phase is extracted twice, each time with 200 ml of methylene chloride, the organic phase is washed with water to pH 6.5 and dried and the organic solvent then evaporated. The desired acid is recrystallized from 500 ml of toluene. The yield is 64%. MP: 159°C.

Therapeutic Function

Antiinflammatory

bucloxic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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bucloxic acid Suppliers

Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9357
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
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58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24648
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58
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
Country
China
ProdList
10009
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58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
14760821013 13564957716
Email
1816280386@qq.com
Country
China
ProdList
7286
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58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19863
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
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58

32808-51-8, bucloxic acidRelated Search:


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  • 32808-51-8