tolycaine
- Product Name
- tolycaine
- CAS No.
- 3686-58-6
- Chemical Name
- tolycaine
- Synonyms
- tolycaine;tolycaine USP/EP/BP;Methyl 2-(2-(diethylaMino)acetaMido)-3-Methylbenzoate;Tolycaine,anesthetic,inhibit,analog,convulsion,Inhibitor;methyl 2-[[2-(diethylamino)acetyl]amino]-3-methylbenzoate;2-[2-(Diethylamino)acetylamino]-m-toluic acid methyl ester;methyl 2-[2-(diethylamino)ethanoylamino]-3-methyl-benzoate;2-[[2-(diethylamino)acetyl]amino]-3-methyl-benzoic acid methyl ester;Benzoic acid, 2-[[(diethylaMino)acetyl]aMino]-3-Methyl-, Methyl ester;Benzoic acid, 2-[[2-(diethylamino)acetyl]amino]-3-methyl-, methyl ester
- CBNumber
- CB1931004
- Molecular Formula
- C15H22N2O3
- Formula Weight
- 278.35
- MOL File
- 3686-58-6.mol
tolycaine Property
- Melting point:
- <25 °C
- Boiling point:
- bp5 190-192°
- Density
- 1.113±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (359.26 mM)
- pka
- 13.61±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- API0008766
- Product name
- TOLYCAINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.32
- Updated
- 2021/12/16
tolycaine Chemical Properties,Usage,Production
Originator
Tolycaine Hydrochloride,ZYF Pharm Chemical
Definition
ChEBI: Tolycaine is an amidobenzoic acid.
Manufacturing Process
A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of
benzene was added 125 ml of saturated solution of sodium acetate and then
at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1
hour at room temperature. The mixture was filtered. The organic layer was
with 10% solution of potassium carbonate and dries under calcium chloride.
By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from
a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl
ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After
cooling the diethyl amine hydrochloride was deleted by filtration. The organic
layer was washed with 2 N hydrochloric acid. To the solution was added
potassium carbonate. The product was extracted with ether and distilled.
brand name
Tolycaine Hydrochloride is JAN.
Therapeutic Function
Local anesthetic
tolycaine Preparation Products And Raw materials
Raw materials
Preparation Products
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