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phenoxybenzamine

Product Name
phenoxybenzamine
CAS No.
59-96-1
Chemical Name
phenoxybenzamine
Synonyms
Phenoxy;Dibenyline;Phenoxybenzamin;phenoxybenzamine USP/EP/BP;N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aMine;N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine;BENZYLAMINE,N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-;Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
CBNumber
CB1933947
Molecular Formula
C18H22ClNO
Formula Weight
303.83
MOL File
59-96-1.mol
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phenoxybenzamine Property

Melting point:
38-40°
Boiling point:
381.5±27.0 °C(Predicted)
Density 
1.0513 (rough estimate)
refractive index 
1.5600 (estimate)
pka
6.58±0.50(Predicted)
color 
Crystals from pet ether
CAS DataBase Reference
59-96-1
EPA Substance Registry System
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine (59-96-1)
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Safety

Hazardous Substances Data
59-96-1(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 2500mg/kg
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Hazard and Precautionary Statements (GHS)

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phenoxybenzamine Chemical Properties,Usage,Production

Originator

Dibenzyline, SKF, US ,1953

Uses

Antihypertensive.

Manufacturing Process

Step 1: In a 500 ml flask equipped with gas inlet tube, dropping funnel and reflux condenser is placed 139 grams of 1-phenoxy-2-propanol. A stream of dry air is bubbled through the alcohol while 55 grams of thionyl chloride is added dropwise with external cooling. The stream of dry air is continued for about six hours or until most of the hydrogen chloride has been expelled and then another 55 grams of thionyl chloride is added. The reaction mixture is allowed to stand twenty-four hours, a few drops of pyridine are added and the mixture heated 4 hours on the steam bath. The cooled reaction mixture is poured into water, the crude product is washed with dilute sodium bicarbonate solution and finally taken up in benzene. The benzene is distilled at ordinary pressure and the residue distilled in vacuo to yield 60-70% of 1-phenoxy-2chloropropane, BP 93°-94°C/5 mm.
Step 2: To 494 grams of ethanolamine, heated to approximately 150°C in a 500 ml flask equipped with stirrer, condenser and dropping funnel, is added 465 grams of 1-phenoxy-2-chloropropane with mechanical stirring. The reaction mixture is then heated to reflux for 3 hours, cooled and poured into a liter of water. The organic layer is extracted into ether and the ether solution is extracted with dilute hydrochloric acid. The aqueous acid solution is then made alkaline with 40% sodium hydroxide solution and the organic base is extracted into ether. Removal of the ether leaves N-(phenoxyisopropyl)ethanolamine which, after recrystallization from hexane, melts at 70.5°-72°C.
Step 3: To 43 grams of N-(phenoxyisopropyl)ethanolamine dissolved in 500 ml of alcohol in a 1,000 ml flask equipped with stirrer and condenser is added 28 grams of benzyl chloride and 18.5 grams of sodium bicarbonate. The mixture is stirred and refluxed for 10 hours and then approximately half the alcohol is removed by distillation. The remaining solution is poured into 500 ml of water and the organic material extracted with 3 100-ml portions of ether. The combined ether extracts are washed with water, dried over anhydrous potassium carbonate and filtered. After removal of the ether, the residue is distilled in vacuo to yield N-(phenoxyisopropyl)-Nbenzylethanolamine, BP 163°-168°C/0.2 mm.
Step 4: A solution of 20 grams of the above amino alcohol is dissolved in 50 ml of dry chloroform and treated with dry hydrogen chloride until acid. Then a solution of 9 grams of thionyl chloride in 50 ml of dry chloroform is added and the reaction mixture is heated on a water bath at 50°-60°C for 2 hours. Most of the chloroform is removed by distillation under reduced pressure. Addition of ether to the residue causes the product to crystallize. After recrystallization from a mixture of alcohol and ether, the N-(phenoxyisopropyl)-N-benzyl-βchloroethylamine hydrochloride melts at 137.5°-140°C.

brand name

Dibenzyline (WellSpring);Dibenzyran.

Therapeutic Function

Adrenergic blocker

World Health Organization (WHO)

Phenoxybenzamine, a long-acting alpha-adrenoreceptor antagonist, was introduced in 1953 and has been used in a variety of peripheral vascular disorders. In 1982 it was shown to have mutagenic activity and in 1985 it was found to be carcinogenic in the rat. Its approved use was subsequently restricted by several regulatory authorities and phenoxybenzamine is currently used to manage hypertensive episodes associated with phaeochromocytoma, as an adjunct to the short-term management of urinary retention due to neurogenic bladder, in the short-term treatment of benign prostatic hypertrophy in patients awaiting surgery, and in inoperable benign prostatic hypertrophy.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intravenous and intracerebral routes. Moderately toxic by ingestion. Human reproductive effects by ingestion: spermatogenesis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

Purification Methods

The free base is crystallised from pet ether, and the HCl is crystallised from EtOH/diethyl ether. [Beilstein 12 IV 2204.]

phenoxybenzamine Preparation Products And Raw materials

Raw materials

Preparation Products

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phenoxybenzamine Suppliers

Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
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58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Email
676046971@qq.com
Country
China
ProdList
4423
Advantage
58
Dideu Industries Group Limited
Tel
029-88380327; 17691182729
Email
Service@dideu.com
Country
CHINA
ProdList
30013
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-571-88938639
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52932
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-89586680
Fax
+86-29-88380327
Email
1005@dideu.com
Country
CHINA
ProdList
9938
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418671
Fax
0551-65418697
Email
sales@tnjchem.com
Country
CHINA
ProdList
37441
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Fax
029-88380327
Email
1017@dideu.com
Country
CHINA
ProdList
3979
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58
Wuhan pengyin Pharmaceutical Co., Ltd
Tel
Email
1939328613@qq.com
Country
China
ProdList
397
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58
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View Lastest Price from phenoxybenzamine manufacturers

Dideu Industries Group Limited
Product
phenoxybenzamine USP/EP/BP 59-96-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-12
Shaanxi Dideu Medichem Co. Ltd
Product
PhenoxybenzaMine Hydrochloride 59-96-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-11

59-96-1, phenoxybenzamineRelated Search:


  • Phenoxybenzamin
  • Phenoxy
  • BENZYLAMINE,N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-
  • Dibenyline
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine
  • N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aMine
  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
  • phenoxybenzamine USP/EP/BP
  • 59-96-1
  • Isotopically Labeled Pharmaceutical Reference Standard