2-Benzhydrylsulphinylacetic acid
- Product Name
- 2-Benzhydrylsulphinylacetic acid
- CAS No.
- 63547-24-0
- Chemical Name
- 2-Benzhydrylsulphinylacetic acid
- Synonyms
- Modavigil;Modafinil Acid;Modafinic Acid;Modafinil EP impurity A;Modafinil Related CoMpound A;Benzyhydrylsulfinylacetic acid;(Benzhydrylsulfinyl)acetic acid;2-Benzhydrylsulphinylacetic acid;Modafinil USP Related Compound A;(Diphenylmethylsulfinyl)acetic acid
- CBNumber
- CB1947221
- Molecular Formula
- C15H14O3S
- Formula Weight
- 274.33
- MOL File
- 63547-24-0.mol
2-Benzhydrylsulphinylacetic acid Property
- Melting point:
- 118-120℃
- Boiling point:
- 539.2±50.0 °C(Predicted)
- Density
- 1.327
- Flash point:
- 2℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.83±0.10(Predicted)
- color
- White to off-white
- BRN
- 665098
- InChIKey
- QARQPIWTMBRJFX-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xi,Xn,F
- Risk Statements
- 41-36-20/21/22-11
- Safety Statements
- 26-39-36/37-16
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 2
- HS Code
- 2930902000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1445346
- Product name
- Modafinil Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $1130
- Updated
- 2025/07/31
- Product number
- API0000663
- Product name
- MODAFINIL CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $721.88
- Updated
- 2021/12/16
- Product number
- API0000663
- Product name
- MODAFINIL CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1732.5
- Updated
- 2021/12/16
- Product number
- A207867
- Product name
- 2-(Benzhydrylsulfinyl)aceticacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $9
- Updated
- 2021/12/16
- Product number
- A207867
- Product name
- 2-(Benzhydrylsulfinyl)aceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
2-Benzhydrylsulphinylacetic acid Chemical Properties,Usage,Production
Chemical Properties
Off-White to Pale Pink Solid
Uses
A metabolite of Modafinil, a central nervous system vigilance promoting agent, which possesses neuroprotective properties
Definition
ChEBI: Modafinil acid is a diarylmethane.
General Description
Modafinil acid is the major metabolite of modafinil, an analeptic drug sold under the brand names Provigil? or Modavigil? and approved by the US FDA for the treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness. Modafinil, a well known nootropic drug, is often used as a performance-enhancing drug in academics and sports.
Synthesis
63547-22-8
63547-24-0
General procedure for the synthesis of 2-diphenylmethylsulfinylacetic acid from 2-[(diphenylmethyl)thio]acetic acid: 1. 2-[(Diphenylmethyl)thio]acetic acid (416 g, 1.61 mol) was suspended in purified water (4160 mL) at 25 to 30°C. 2. a 30% sodium hydroxide solution was prepared by dissolving 70.90 g (1.77 mol) of sodium hydroxide flakes/granules in 235 mL of purified water at 25 to 30 °C and added to the above suspension over 15 min. 3. 50% hydrogen peroxide (142.5 g, 2.095 mol) was slowly added over a period of 5 to 6 hours under stirring, maintaining the reaction temperature between 25 and 35 °C. 4. continue stirring the reaction mixture at 25 to 35 °C for 15 to 20 hours until the reaction is complete (the residual amount of feedstock should be less than 0.5% area). 5. Upon completion of the reaction, toluene (1664 mL) is added and the mixture is stirred for 10 minutes. 6. With stirring, the reaction mixture is acidified with concentrated hydrochloric acid (250 mL) while maintaining the temperature between 25 and 30°C. The reaction mixture is then purified by adding toluene (1664 mL). 7. the resulting substance was continued to be stirred at 25 to 30 °C for 1 hour. 8. The precipitated product was collected by filtration, washed sequentially with water (3 x 832 mL) and toluene (416 mL), and then dried to give 416 g of 2-[(diphenylmethyl)sulfinyl]acetic acid as a white crystalline powder (yield: 94.17%, HPLC purity: 99.3%).
References
[1] Organic and Biomolecular Chemistry, 2017, vol. 15, # 12, p. 2647 - 2654
[2] Patent: WO2009/24863, 2009, A2. Location in patent: Page/Page column 14-15
[3] Patent: WO2009/24863, 2009, A2. Location in patent: Page/Page column 16-17
[4] Patent: WO2009/24863, 2009, A2. Location in patent: Page/Page column 16
[5] Patent: WO2009/24863, 2009, A2. Location in patent: Page/Page column 15-16
2-Benzhydrylsulphinylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Benzhydrylsulphinylacetic acid manufacturers
- Product
- 2-Benzhydrylsulphinylacetic acid 63547-24-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-18
- Product
- 2-Benzhydrylsulphinylacetic acid 63547-24-0
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25