ChemicalBook > CAS DataBase List > 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

Product Name: 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)
CAS No.: 192214-06-5
Chemical Name: 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)
Synonyms: C67151;N-Cbz-R-3-Pyrrolidinecarboxylic acid;(R)-1-Cbz-3-pyrrolidinecarboxylic acid;(R)-N-Cbz-3-pyrrolidinecarboxylic Acid;(R )-1-Cbz-pyrrolidine-3-carboxylic acid;(R)-1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID;1-(Benzyl) (3R)-1,3-pyrrolidinedicarboxylate;1-(Phenylmethyl) (3R)-1,3-pyrrolidinedicarboxylate;(R)-1-Cbz-pyrrolidine-3-carboxylic acid - [P12342];(3R)-1-benzyloxycarbonylpyrrolidine-3-carboxylic acid
CBNumber: CB1948253
Molecular Formula: C13H15NO4
Formula Weight: 249.26
MOL File: 192214-06-5.mol

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1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R) Property

Boiling point:: 432.3±45.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.46±0.20(Predicted)
Appearance: White to off-white Solid
optical activity: -18.2°(C=0.01 g/mI, CHCL3, 20°C, 589nm)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C227640
Product name: (R)-1-Cbz-pyrrolidine-3-carboxylicacid
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Activate Scientific

Product number: AS24682
Product name: (R)-N-Cbz-3-pyrrolidinecarboxylic Acid
Purity: 97+% ee
Packaging: 250mg
Price: $53
Updated: 2021/12/16

Synthonix

Product number: P12342
Product name: (R)-1-Cbz-pyrrolidine-3-carboxylicacid
Purity: 95+%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Activate Scientific

Product number: AS24682
Product name: (R)-N-Cbz-3-pyrrolidinecarboxylic Acid
Purity: 97+% ee
Packaging: 1g
Price: $112
Updated: 2021/12/16

AK Scientific

Product number: 9983AA
Product name: (R)-1-Cbz-Pyrrolidine-3-carboxylicacid
Packaging: 1g
Price: $127
Updated: 2021/12/16

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1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R) Chemical Properties,Usage,Production

Synthesis

192214-05-4

192214-06-5

Step 3: Preparation of (R)-1-benzyloxycarbonyl-pyrrolidine-3-carboxylic acid (X): (R)-(1-benzyloxycarbonyl-pyrrolidin-3-yl)-methanol (IX, 80 g) was dissolved in acetone (800 ml), and Jones' reagent (200 ml, prepared by dissolving 53.4 g of CrO3 in 46 ml of H2SO4 and 140 ml of water under stirring) was added dropwise. solution, the final volume was adjusted to 200 mL). The reaction was carried out at 20 °C until the solution took on a deep red color and green solids precipitated. The suspension was continued to be stirred for 30 min. After confirming that the reaction was complete by thin layer chromatography (TLC, the unfolding agent was a chloroform solution of 10% methanol), isopropanol (100 ml) was added drop by drop to quench the reaction and the green color lasted for 10 minutes. The reaction mixture was filtered through a bed of diatomaceous earth and the solid was washed with fresh acetone (100 mL, twice). The filtrate was concentrated under vacuum and the residue was adjusted to pH 8 by addition of saturated aqueous sodium bicarbonate (600 ml).The resulting mixture was extracted with ethyl acetate (400 ml) to separate the organic and aqueous layers. The aqueous layer was adjusted to pH 2 with aqueous 6N hydrochloric acid (125 ml) and then extracted with ethyl acetate (500 ml x 2). The organic layers were combined, dried with sodium sulfate, and the solvent evaporated to give 67 g of (R)-1-benzyloxycarbonyl-pyrrolidine-3-carboxylic acid (X) as an oily syrup in 79% yield. The product was analyzed by nuclear magnetic resonance (NMR, CDCl3) and mass spectrometry (MS) to confirm: NMR (CDCl3): δ 9.25 (br s, 1H), 7.25-7.35 (m, 5H), 5.13 (s, 2H), 3.62-3.71 (m, 2H), 3.52-3.54 (m, 1H), 3.43-3.49 (m, 1H). 3.07-3.10 (m, 1H), 2.09-2.18 (m, 2H). Mass spectrum (M-1): 248.1 for C14H15NO4.

References

[1] Journal of Organic Chemistry, 1997, vol. 62, # 15, p. 5215 - 5218
[2] Patent: WO2014/135932, 2014, A1. Location in patent: Page/Page column 12; 13

1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R) Preparation Products And Raw materials

Raw materials

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View Lastest Price from 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R) manufacturers

Career Henan Chemical Co

Product: N-Cbz-R-3-Pyrrolidinecarboxylic acid 192214-06-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

192214-06-5, 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)Related Search:

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,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

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(R)-1-Cbz-pyrrolidine-3-carboxylic acid - [P12342]

1-(Benzyl) (3R)-1,3-pyrrolidinedicarboxylate

192214-06-5

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