tert-Butyl piperidine-4-carboxylate
- Product Name
- tert-Butyl piperidine-4-carboxylate
- CAS No.
- 138007-24-6
- Chemical Name
- tert-Butyl piperidine-4-carboxylate
- Synonyms
- tert-Butyl 4-Piperidinecarboxylate;Tert-Butyl Piperidine-4-Carboxylate;4-tert-butyl piperidine-4-carboxylate;4-Piperidine carboxylic acid t-butyl ester;4-Piperidinecarboxylic acid tert-butyl ester;Piperidine-4-carboxylic acid tert-butyl ester;4-Piperidinecarboxylic acid, 1,1-diMethylethyl ester;4-Piperidinecarboxylic acid tert-butyl ester hydrochloride
- CBNumber
- CB1972058
- Molecular Formula
- C10H19NO2
- Formula Weight
- 185.26
- MOL File
- 138007-24-6.mol
tert-Butyl piperidine-4-carboxylate Property
- Boiling point:
- 241.0±33.0 °C(Predicted)
- Density
- 0.976±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 9.78±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-Liquid Mixture
- InChI
- InChI=1S/C10H19NO2/c1-10(2,3)13-9(12)8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3
- InChIKey
- FUYBPBOHNIHCHM-UHFFFAOYSA-N
- SMILES
- N1CCC(C(OC(C)(C)C)=O)CC1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B812548
- Product name
- tert-Butylpiperidine-4-carboxylate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR944680
- Product name
- tert-Butylpiperidine-4-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR944680
- Product name
- tert-Butylpiperidine-4-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $395
- Updated
- 2021/12/16
- Product number
- CHM0146944
- Product name
- 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $791.52
- Updated
- 2021/12/16
- Product number
- CHM0146944
- Product name
- 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $866.13
- Updated
- 2021/12/16
tert-Butyl piperidine-4-carboxylate Chemical Properties,Usage,Production
Synthesis
882738-24-1
138007-24-6
Wet Degussa-type Pd/C catalyst (10% Pd, 50% water content, 8.120 g, 76.30 mmol) was added to a 3 L three-necked flask under nitrogen protection, followed by EtOAc (1.706 L). The mixture was degassed by a nitrogen/vacuum cycle (3 times). Then, a solution of EtOAc (243.7 mL) of 1-benzyl-4-tert-butylpiperidine-1,4-dicarboxylate (243.7 g, 763.0 mmol) was added. The reaction mixture was stirred overnight under hydrogen atmosphere. After supplementing with hydrogen, stirring was continued for 3.5 hours. Methanol (60 mL) was added to promote dissolution of the precipitate, which was subsequently filtered through a diatomaceous earth pad and washed with methanol. The filtrate was concentrated under reduced pressure to give a brown oil (138.6 g) containing a small amount of white solid. The solid was removed by filtration and washed with a minimal amount of EtOAc. The filtrate was again concentrated under reduced pressure to give tert-butyl piperidine-4-carboxylate (129 g, 91% yield) as a light brown oil. The product was characterized by 1H NMR (500 MHz, DMSO-d6) with chemical shifts of δ 2.88 (dt, 2H), 2.44 (td, 2H), 2.23 (tt, 1H), 1.69-1.64 (m, 2H), 1.41-1.33 (m, 11H).
References
[1] Patent: US2015/158872, 2015, A1. Location in patent: Paragraph 0508; 0510
[2] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 29
[3] Patent: WO2015/65866, 2015, A1. Location in patent: Page/Page column 32
tert-Butyl piperidine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl piperidine-4-carboxylate Suppliers
- Tel
- 021-57790084; 13918007836
- Fax
- 021-51685238
- sales@hoborchem.com
- Country
- China
- ProdList
- 392
- Advantage
- 60
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- +86 (21) 6715-7650
- Fax
- +86 (21) 6715-7651
- sheepchem@163.com
- Country
- China
- ProdList
- 994
- Advantage
- 60
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
- ProdList
- 5001
- Advantage
- 55
View Lastest Price from tert-Butyl piperidine-4-carboxylate manufacturers
- Product
- 4-Piperidinecarboxylicacidt-butylesterHCl 138007-24-6
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10