Keverprazan Hydrochloride

Product Name: Keverprazan Hydrochloride
CAS No.: 2209911-80-6
Chemical Name: Keverprazan Hydrochloride
Synonyms: Carenoprazan HCl;P-CAB agent 2 hydrochloride;1-(5-(2-Fluorophenyl)-1-((3-(3-methoxypropoxy)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine hydrochloride;1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1)
CBNumber: CB19942397
Molecular Formula: C22H26ClFN2O4S
Formula Weight: 468.97
MOL File: 2209911-80-6.mol

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Keverprazan Hydrochloride Property

form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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Keverprazan Hydrochloride Chemical Properties,Usage,Production

Uses

P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].

in vivo

P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats^[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats^[1].

Animal Model:	180-220 g, SPF grade, male SD rats^[1]
Dosage:	2 mg/kg
Administration:	P.o.; once
Result:	Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.

References

[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.

Keverprazan Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Keverprazan Hydrochloride Suppliers

China 11 United States 1 Global 12

CONIER CHEM AND PHARMA LIMITED

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Nanjing webright Pharmaceutical Technology Co., Ltd

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Bide Pharmatech Ltd.

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NanJing Vtrying Pharmatech Co.,Ltd

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Nantong QuanYi Biotechnology Co., Ltd

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TargetMol Chemicals Inc.

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Hubei Rhema Reference Materials Technology Co., Ltd.

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Shanghai trilet state biological pharmaceutical Technology Co., LTD

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TargetMol Chemicals Inc.

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Nanjing Bicbiotechnology Co., Ltd

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2209911-80-6, Keverprazan HydrochlorideRelated Search:

1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1)

P-CAB agent 2 hydrochloride

1-(5-(2-Fluorophenyl)-1-((3-(3-methoxypropoxy)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine hydrochloride

Carenoprazan HCl

2209911-80-6

C22H26ClFN2O4S