AM555S,TAC-101

Product Name: AM555S,TAC-101
CAS No.: 125973-56-0
Chemical Name: AM555S,TAC-101
Synonyms: CS-893;AM 555S;AMsilarotene;AM555S,TAC-101;TAC 101; TAC101;AMsilarotene (TAC-101);Amsilarotene, 10 mM in DMSO;4-(3,5-bis(trimethylsilyl)benzamido)benzoic acid;4-[[3,5-Bis(trimethylsilyl)benzoyl]amino]benzoic acid;Benzoic acid,4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-
CBNumber: CB21011069
Molecular Formula: C20H27NO3Si2
Formula Weight: 385.6
MOL File: 125973-56-0.mol

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AM555S,TAC-101 Property

Melting point:: 280℃ (decomposition)
Boiling point:: 403.3±45.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (259.34 mM; Need ultrasonic)
form: Solid
pka: 4.28±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005321
Product name: TAC-101
Purity: 95.00%
Packaging: 5MG
Price: $503.76
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005321
Product name: TAC-101
Purity: 95.00%
Packaging: 100MG
Price: $2317.35
Updated: 2021/12/16

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AM555S,TAC-101 Chemical Properties,Usage,Production

Uses

Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer[1][2][3].

in vivo

Amsilarotene (8 mg/kg/day orally for 30 days) inhibits the RMG-II tumor growth in nude mice^[2].

Animal Model:	6-week-old female BALB/c nu/nu mice with subcutaneous RMG-II tumors^[2]
Dosage:	8 mg/kg/day
Administration:	Orally for 30 days
Result:	The maximal tumor growth-inhibiting effect was seen on day 31 of administration, when there was a 45% reduction of relative tumor volume (RTV).

References

[1] Sun SY, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997 Nov 1;57(21):4931-9. PMID:9354460
[2] Suzuki N, et al. A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. Gynecol Oncol. 2004 Sep;94(3):643-9. DOI:10.1016/j.ygyno.2004.06.026
[3] Fujimoto K, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999 May 17;81(4):637-44. DOI:10.1002/(sici)1097-0215(19990517)81:43.0.co;2-4

AM555S,TAC-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM555S,TAC-101 Suppliers

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125973-56-0, AM555S,TAC-101Related Search:

Poly(dimethylsiloxane) AM555S,TAC-101 1,3-BIS(TRIMETHYLSILYL)BENZENE 4-(3,5-BIS-TRIMETHYLSILANYL-BENZOYLAMINO)-BENZOIC ACID METHYL ESTER

AM555S,TAC-101

AM 555S

AMsilarotene

AMsilarotene (TAC-101)

4-[[3,5-Bis(trimethylsilyl)benzoyl]amino]benzoic acid

CS-893

4-(3,5-bis(trimethylsilyl)benzamido)benzoic acid

Benzoic acid,4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-

TAC 101; TAC101

AsPC-1,Apoptosis,orally active,Retinoid X receptors,cancer,Inhibitor,RAR/RXR,inhibit,RMG-II,MIAPaCa-2,BxPC-3,Am 555S,Amsilarotene,Retinoic acid receptors

Amsilarotene, 10 mM in DMSO

125973-56-0

C20H27NO3Si2