ChemicalBook > CAS DataBase List > RUBOXISTAURIN MESYLATE

RUBOXISTAURIN MESYLATE

Product Name
RUBOXISTAURIN MESYLATE
CAS No.
169939-94-0
Chemical Name
RUBOXISTAURIN MESYLATE
Synonyms
Ruboxistaurin;SM-030;CS-1578;DBI-102;LY 333531;Unii-721809wqcp;LY 333531; LY 333531;RUBOXISTAURIN MESYLATE;Ruboxistaurin free base;Ruboxistaurin (LY333531)
CBNumber
CB21011751
Molecular Formula
C28H28N4O3
Formula Weight
468.55
MOL File
169939-94-0.mol
More
Less

RUBOXISTAURIN MESYLATE Property

Boiling point:
744.4±60.0 °C(Predicted)
Density 
1.34
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (106.71 mM; ultrasonic and warming and heat to 60°C)
pka
8.26±0.40(Predicted)
form 
Solid
color 
Brown to reddish brown
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
474178
Product name
Ruboxistaurin
Packaging
100mg
Price
$2994
Updated
2021/12/16
Biosynth Carbosynth
Product number
FR61574
Product name
Ruboxistaurin
Packaging
10mg
Price
$245
Updated
2021/12/16
AK Scientific
Product number
0655CB
Product name
Ruboxistaurin
Packaging
10mg
Price
$380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0002580
Product name
RUBOXISTAURIN
Purity
95.00%
Packaging
5MG
Price
$502.54
Updated
2021/12/16
Biosynth Carbosynth
Product number
FR61574
Product name
Ruboxistaurin
Packaging
50mg
Price
$857.5
Updated
2021/12/16
More
Less

RUBOXISTAURIN MESYLATE Chemical Properties,Usage,Production

Uses

Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.

in vivo

Ruboxistaurin (1 mg/kg; 8 weeks) markedly reduces GEC apoptosis as well as swiprosin-1 upregulation, and ameliorates renal glomerular injury in the diabetic mice. Ruboxistaurin also potently attenuates the expression of PARP, cleaved-caspase9, cleaved-caspase3, and the Bax/Bcl-2 ratio, in diabetic mice[3]. Ruboxistaurin (0.1, 1.0, or 10.0 mg/kg; p.o.) dramatically reduces the number of leukocytes trapped in the retinal microcirculation of diabetic rats[4].

Animal Model:Rats[4]
Dosage:0.1, 1.0, or 10.0 mg/kg
Administration:P.o.
Result:Dramatically reduced the number of leukocytes trapped in the retinal microcirculation of diabetic rats.

IC 50

PKC-βI: 4.7 nM (IC50); PKC-βII: 5.9 nM (IC50); PKCη: 52 nM (IC50); PKCδ: 250 nM (IC50); PKCγ: 300 nM (IC50); PKCα: 360 nM (IC50); PKCε: 600 nM (IC50)

RUBOXISTAURIN MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

RUBOXISTAURIN MESYLATE Suppliers

China 42 The Netherlands 1 United Kingdom 1 United States 6 Global 50
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
More
Less

View Lastest Price from RUBOXISTAURIN MESYLATE manufacturers

Career Henan Chemical Co
Product
RUBOXISTAURIN MESYLATE 169939-94-0
Price
US $0.01/KG
Min. Order
500g
Purity
98%; 99%
Supply Ability
500g；1kg； 10kg; 25kg
Release date
2020-01-08

169939-94-0, RUBOXISTAURIN MESYLATERelated Search:


  • 9H,18H-5,21:12,17-Dimethenodibenzo(E,K)pyrrolo(3,4-H)(1,4,13)oxadiazacyclohexadecine-18,20(19H)-dione, 9-((dimethylamino)methyl)-6,7,10,11-tetrahydro-, (9S)-
  • Unii-721809wqcp
  • Ruboxistaurin (LY333531)
  • Ruboxistaurin (LY333531) (HCl salt)
  • RUBOXISTAURIN MESYLATE
  • (S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione
  • LY 333531
  • Ruboxistaurin
  • 13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(E,K)pyrrolo(3,4-H)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione
  • CS-1578
  • LY 333531; LY 333531
  • (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1?,1?.02,?.0?,13.022,2?]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione
  • (7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione
  • DBI-102
  • SM-030
  • Ruboxistaurin free base
  • (12e,32e,7s)-7-((dimethylamino)methyl)-22,25-dihydro-11h,21h,31h-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione methanesulfonate
  • 169939-94-0