O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane

Product Name: O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane
CAS No.: 54805-58-2
Chemical Name: O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane
Synonyms: AB-182;O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane;Carbamic acid, [[bis(2,2-dimethyl-1-aziridinyl)phosphinyl]oxy]-, ethyl ester (9CI)
CBNumber: CB21016756
Molecular Formula: C11H22N3O4P
Formula Weight: 291.28
MOL File: 54805-58-2.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0308397
Product name: O-(BIS(2,2-DIMETHYL-1-AZIRIDINYL)PHOSPHINYL)-N-HYDROXYURETHANE
Purity: 95.00%
Packaging: 5MG
Price: $496.83
Updated: 2021/12/16

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O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane Chemical Properties,Usage,Production

Description

AB-182 is an aziridine derivative and antitumor agent.

Uses

AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups.

References

[1] Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979;5(9):1653-1656. DOI:10.1016/0360-3016(79)90791-0
[2] Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979;5(9):1677-1680. DOI:10.1016/0360-3016(79)90796-x

O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane Preparation Products And Raw materials

Raw materials

Preparation Products

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O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane Suppliers

China 1 United States 2 Global 3

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29358
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

54805-58-2, O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethaneRelated Search:

2,2-dimethylaziridine N-Hydroxyurethane O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane

O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane

AB-182

Carbamic acid, [[bis(2,2-dimethyl-1-aziridinyl)phosphinyl]oxy]-, ethyl ester (9CI)

54805-58-2

C11H22N3O4P