Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)-
- Product Name
- Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)-
- CAS No.
- 52558-24-4
- Chemical Name
- Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)-
- Synonyms
- Boc-IsoSer-OH;Boc-Isoserine-OH;Boc-(S)-isoserine;N-tert-Butyloxycarbonyl-(S)-isoserine;(S)-3-(Boc-aMino)-2-hydroxy-propanoic acid;3-tert-ButoxycarbonylaMino-(S)-2-hydroxy-propionic acid;(S)-3-((tert-Butoxycarbonyl)aMino)-2-hydroxypropanoic acid;(S)-3-(tert-Butyloxycarbonylamino)-2-hydroxypropionic acid;(2S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-propanoic acid;(2S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
- CBNumber
- CB21050291
- Molecular Formula
- C8H15NO5
- Formula Weight
- 205.21
- MOL File
- 52558-24-4.mol
Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- Property
- Boiling point:
- 391.7±32.0 °C(Predicted)
- Density
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.58±0.11(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- Consistent with structure
- InChI
- InChI=1S/C8H15NO5/c1-8(2,3)14-7(13)9-4-5(10)6(11)12/h5,10H,4H2,1-3H3,(H,9,13)(H,11,12)/t5-/m0/s1
- InChIKey
- JJCAYTVAYSGVLA-YFKPBYRVSA-N
- SMILES
- C(O)(=O)[C@@H](O)CNC(OC(C)(C)C)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- CS-W021169
- Product name
- (S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxypropanoicacid
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- FB142045
- Product name
- (S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxypropanoic acid
- Packaging
- 100mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- CS-W021169
- Product name
- (S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxypropanoicacid
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FB142045
- Product name
- (S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxypropanoic acid
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FB142045
- Product name
- (S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxypropanoic acid
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- Chemical Properties,Usage,Production
Synthesis
565-71-9
24424-99-5
52558-24-4
(S)-Isoserine (21 g, 0.20 mol) was dissolved in tetrahydrofuran (100 mL), followed by addition of a solvent mixture of 10% aqueous sodium hydroxide (100 mL) and di-tert-butyl dicarbonate (50 mL, 0.22 mol). The reaction mixture was stirred at room temperature for 9 hours. After completion of the reaction, the aqueous phase was adjusted to pH 2 with 4 mol/L hydrochloric acid and then extracted with dichloromethane/methanol (v/v=5/1, 50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After drying, the desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give 3-tert-butoxycarbonylamino-(S)-2-hydroxypropionic acid as a colorless oil (35 g, yield: 85%).
References
[1] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[2] Journal of Organic Chemistry, 2018, vol. 83, # 9, p. 4973 - 4980
[3] Patent: CN108341752, 2018, A. Location in patent: Paragraph 0507; 0508; 0509; 0510
[4] Patent: WO2010/132757, 2010, A2. Location in patent: Page/Page column 98-99
[5] Patent: WO2011/44503, 2011, A1. Location in patent: Page/Page column 67
Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- manufacturers
- Product
- Boc-Isoserine 52558-24-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2023-10-11