Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
- Product Name
- Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 501907-61-5
- Chemical Name
- Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- N-Boc-4-Amino-2,6-dichloropyridine;tert-Butyl (2,6-dichloropyridin-4-yl);t-butyl 2,6-dichloropyridin-4-yl-carbamate;1-N-Boc-4-aMino-2-chloro-3-forMylpyridine ;ert-Butyl(2,6-dichloropyridin-4-yl)carbamate;tert-butyl (2,6-dichloropyridin-4-yl)carbamate;tert-butyl N-(2,6-dichloropyridin-4-yl)carbamate;(2,6-Dichloropyridin-4-yl)carbamic acid tert-butyl ester;(2,6-dichloro-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI);Carbamic acid, N-(2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB21053924
- Molecular Formula
- C10H12Cl2N2O2
- Formula Weight
- 263.12
- MOL File
- 501907-61-5.mol
Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Property
- Boiling point:
- 309.6±42.0 °C(Predicted)
- Density
- 1.345
- storage temp.
- 2-8°C
- pka
- 11.30±0.70(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB143663
- Product name
- tert-Butyl (2,6-dichloropyridin-4-yl)carbamate
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- W6554
- Product name
- tert-Butyl(2,6-dichloropyridin-4-yl)carbamate
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FB143663
- Product name
- tert-Butyl (2,6-dichloropyridin-4-yl)carbamate
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 118946
- Product name
- tert-Butyl (2,6-dichloropyridin-4-yl)carbamate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FB143663
- Product name
- tert-Butyl (2,6-dichloropyridin-4-yl)carbamate
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
2587-02-2
24424-99-5
501907-61-5
Step 1. 4-Amino-2,6-dichloropyridine (5.04 g, 30.3 mmol) was dissolved in dichloromethane (DCM, 100 mL) at room temperature, and 4-dimethylaminopyridine (DMAP, 0.61 g, 4.99 mmol) and di-tert-butyl dicarbonate (Boc2O, 13.71 g, 60.9 mmol) were added sequentially. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the organic phase was washed sequentially with saturated aqueous ammonium chloride solution (3 × 30 mL) and brine (40 mL), followed by drying and concentration with anhydrous sodium sulfate. The residue was dissolved in a solvent mixture of tetrahydrofuran (THF, 30 mL) and water (30 mL) and sodium hydroxide (4.5 g, 112 mmol) was added. The reaction mixture was heated at 65 °C for 4 h. After cooling to room temperature, it was extracted with ethyl acetate (EtOAc, 5 × 30 mL). The organic phases were combined and washed sequentially with 1N hydrochloric acid (2 × 30 mL) and water (40 mL), followed by drying and concentration with anhydrous sodium sulfate to give a solid product. The solid was collected by filtration, washed sequentially with 1N hydrochloric acid (4 × 10 mL) and water (20 mL), and finally dried in a vacuum oven at 50 °C to afford N-Boc-4-amino-2,6-dichloropyridine (7.44 g, 93% yield) as a white solid.
References
[1] Patent: WO2015/76800, 2015, A1. Location in patent: Page/Page column 292
[2] Tetrahedron Letters, 2006, vol. 47, # 50, p. 8917 - 8920
[3] Journal of Organic Chemistry, 2008, vol. 73, # 15, p. 6025 - 6028
[4] Patent: WO2016/6974, 2016, A2. Location in patent: Paragraph 516; 517; 518; 519; 520; 521; 522
Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
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View Lastest Price from Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) manufacturers
- Product
- Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) 501907-61-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06