Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)
- Product Name
- Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)
- CAS No.
- 386715-33-9
- Chemical Name
- Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)
- Synonyms
- 2-(trifluoromethyl)-5-chloromethyl pyridine;Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)-;5-(Chloromethyl)-2-(trifluoromethyl)pyridine97%;Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI);5-Chloromethyl-2-(trifluoromethyl)pyridine, CAS 386715-33-9
- CBNumber
- CB21066296
- Molecular Formula
- C7H5ClF3N
- Formula Weight
- 195.57
- MOL File
- 386715-33-9.mol
Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Property
- Boiling point:
- 110°C/19mm
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Solid-liquid mixture
- InChI
- InChI=1S/C7H5ClF3N/c8-3-5-1-2-6(12-4-5)7(9,10)11/h1-2,4H,3H2
- InChIKey
- PRPAYPBERKUDKO-UHFFFAOYSA-N
- SMILES
- C1(C(F)(F)F)=NC=C(CCl)C=C1
Safety
- RIDADR
- 3265
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C588000
- Product name
- 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC7749
- Product name
- 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 3H32-7-22
- Product name
- 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 006828
- Product name
- 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 006828
- Product name
- 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Chemical Properties,Usage,Production
Synthesis
386704-04-7
386715-33-9
General procedure for the synthesis of 5-chloromethyl-2-trifluoromethylpyridine from 6-trifluoromethyl-3-pyridine methanol: At room temperature and under nitrogen protection, [6-(trifluoromethyl)pyridin-3-yl]methanol (4.41 g, 24.9 mmol) was dissolved in anhydrous dichloromethane (82.5 ml) and triethylamine (4.2 ml, 30.1 mmol) and 4-dimethylamino pyridine (21.5 mg, 0.176 mmol). The reaction mixture was cooled to 0 °C, methanesulfonyl chloride (3.0 ml, 38.8 mmol) was added slowly dropwise and stirred at 0 °C for 1 h. The mixture was gradually warmed up to room temperature and continued to be stirred for 22 h. After the reaction was completed, the reaction was carried out at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent ratio of hexane:ethyl acetate=9:1→1:1 to afford 5-(chloromethyl)-2-trifluoromethylpyridine. The yield was 3.99 g, 84%, as yellow liquid.
References
[1] Patent: JP2017/178911, 2017, A. Location in patent: Paragraph 0133; 0134
[2] Patent: US2013/131036, 2013, A1. Location in patent: Paragraph 1574; 1575
[3] Patent: WO2013/62966, 2013, A2. Location in patent: Paragraph 101; 102
[4] Patent: US2014/107340, 2014, A1. Location in patent: Paragraph 0116
[5] Organic Letters, 2017, vol. 19, # 14, p. 3895 - 3898
Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) manufacturers
- Product
- Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) 386715-33-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-27
- Product
- Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) 386715-33-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19