Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- Product Name
- Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 167216-17-3
- Chemical Name
- Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- Boc-(R)-3-aminobutan-1-ol;(R)-N-BOC-3-AMINOBUTAN-1-OL;N-Boc-(R)-3-aminobutan-1-ol;N-(t-Butoxycarbonyl)-L-β-homoalaninol;(R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate;tert-Butyl (R)-(4-hydroxybutan-2-yl)carbamate;tert-butyl N-[(1R)-3-hydroxy-1-methyl-propyl]carbamate;(-)-tert-butyl [(R)-3-hydroxy-1-methylpropyl]carbamate;Carbamic acid, N-[(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester;Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- CBNumber
- CB21072347
- Molecular Formula
- C9H19NO3
- Formula Weight
- 189.25
- MOL File
- 167216-17-3.mol
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Property
- Boiling point:
- 301.4±25.0 °C(Predicted)
- Density
- 1.010±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.32±0.46(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- Consistent with structure
- InChI
- InChI=1S/C9H19NO3/c1-7(5-6-11)10-8(12)13-9(2,3)4/h7,11H,5-6H2,1-4H3,(H,10,12)/t7-/m1/s1
- InChIKey
- JSZOAOLSEKSNTD-SSDOTTSWSA-N
- SMILES
- C(OC(C)(C)C)(=O)N[C@H](C)CCO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AAA0010173
- Product name
- BOC-BETA-HOMOALA-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.49
- Updated
- 2021/12/16
- Product number
- 4619DD
- Product name
- (R)-Tert-Butyl(4-hydroxybutan-2-yl)carbamate
- Packaging
- 5g
- Price
- $606
- Updated
- 2021/12/16
- Product number
- A292400
- Product name
- (R)-tert-Butyl(4-hydroxybutan-2-yl)carbamate
- Purity
- 95%
- Packaging
- 10g
- Price
- $669
- Updated
- 2021/12/16
- Product number
- CM250168
- Product name
- (R)-tert-Butyl(4-hydroxybutan-2-yl)carbamate
- Purity
- 95%
- Packaging
- 10g
- Price
- $701
- Updated
- 2021/12/16
- Product number
- A292400
- Product name
- (R)-tert-Butyl(4-hydroxybutan-2-yl)carbamate
- Purity
- 95%
- Packaging
- 25g
- Price
- $1295
- Updated
- 2021/12/16
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
159877-47-1
167216-17-3
General procedure for the synthesis of tert-butyl (R)-(4-hydroxybutan-2-yl)carbamate from methyl (R)-N-Boc-3-aminobutyrate: To a solution of methyl (R)-3-((tert-butoxycarbonyl)amino)butyrate (3.0 g, 14.76 mmol) in tetrahydrofuran (THF) (50 mL) was slowly added lithium aluminum (0.728 g, 19.19 mmol) hydroxide (0.728 g, 19.19 mmol) at -78°C under nitrogen protection. Lithium aluminum hydride (0.728 g, 19.19 mmol) was added slowly at -78°C under nitrogen protection. The reaction mixture was stirred at this temperature for 1 hour. Subsequently, the reaction system was slowly warmed to 0°C and the reaction was quenched by dropwise addition of water (0.7 mL) and 15% NaOH aqueous solution (0.7 mL). After quenching, the mixture was stirred at room temperature for 1 h and then filtered through a diatomaceous earth pad. The filtrate was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give tert-butyl (R)-(4-hydroxybutan-2-yl)carbamate (1.3 g).
References
[1] Advanced Synthesis and Catalysis, 2010, vol. 352, # 1, p. 92 - 96
[2] Patent: US2011/237814, 2011, A1. Location in patent: Page/Page column 11
[3] Patent: WO2014/114249, 2014, A1. Location in patent: Page/Page column 21
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) manufacturers
- Product
- (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate 167216-17-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 1000kg
- Release date
- 2025-11-05