ChemicalBook > CAS DataBase List > 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride

1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride

Product Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
CAS No.: 76778-22-8
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
Synonyms: CS-1257;GBR 12935;GBR12935;GBR-12935;GBR 12935 mesylate;GBR-12935 free base;(DIPHENYLMETHOXY)GBR - 12935;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl);1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)pi;1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine;1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine
CBNumber: CB21075414
Molecular Formula: C28H34N2O
Formula Weight: 414.58
MOL File: 76778-22-8.mol

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1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Property

Boiling point:: 540.6±50.0 °C(Predicted)
Density: 1.067±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 7.55±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B193930
Product name: 1-(2-(Benzhydryloxy)ethyl-4-(3-phenylpropyl)piperazine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FG65031
Product name: GBR 12935 mesylate
Packaging: 10mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: Y0450
Product name: 1-(2-Benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine
Packaging: 10mg
Price: $124
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611503
Product name: GBR 12935
Packaging: 100mg
Price: $277.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611503
Product name: GBR 12935
Packaging: 250mg
Price: $414.8
Updated: 2021/12/16

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1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Chemical Properties,Usage,Production

Uses

GBR 12935 is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 also prevents the d-Fenfluramine-induced head-twitch response in mice[1][2][3][4].

Definition

ChEBI: An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat stria al membranes).

Biological Activity

Potent and selective inhibitor of dopamine uptake (K D = 5.5 nM in rat striatal membranes).

in vivo

GBR 12935 (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections^[3].

Animal Model:	Adult male DBA/2J and C57BL/6J mice (22-30 g)^[3]
Dosage:	1.0, 3.2, 10, 32 mg/kg
Administration:	Repeat injection; for 7 days
Result:	Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice. No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline.

References

[1] Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. DOI:10.1016/s0006-2952(97)00172-x
[2] Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44. DOI:10.1016/s0014-2999(01)00785-3
[3] Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9. DOI:10.1016/0091-3057(94)90340-9
[4] Darmani NA. Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice. Pharmacol Biochem Behav. 1998 May;60(1):83-90. DOI:10.1016/s0091-3057(97)00548-0

1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Preparation Products And Raw materials

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View Lastest Price from 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)pi 76778-22-8
Price: US $8.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

Career Henan Chemical Co

Product: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride 76778-22-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-17

76778-22-8, 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochlorideRelated Search:

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1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine

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CS-1257

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GBR-12935 free base

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76778-22-8

C28H34N2O

Dopamine receptor