ChemicalBook > CAS DataBase List > 4-Pyrimidinecarbonitrile, 2-amino- (9CI)
4-Pyrimidinecarbonitrile, 2-amino- (9CI)
- Product Name
- 4-Pyrimidinecarbonitrile, 2-amino- (9CI)
- CAS No.
- 36314-98-4
- Chemical Name
- 4-Pyrimidinecarbonitrile, 2-amino- (9CI)
- Synonyms
- 2-amipyrimidine-4-carbonitrile;2-Amino-4-pyrimidinecarbonitrile;2-aminopyrimidine-4-carbonitrile;4-Pyrimidinecarbonitrile,2-amino-;4-Pyrimidinecarbonitrile, 2-amino- (9CI);4-Pyrimidinecarbonitrile, 2-amino- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB21081914
- Molecular Formula
- C5H4N4
- Formula Weight
- 120.11
- MOL File
- 36314-98-4.mol
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4-Pyrimidinecarbonitrile, 2-amino- (9CI) Property
- Melting point:
- 222 °C (decomp)
- Boiling point:
- 387.9±34.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.63±0.10(Predicted)
- Appearance
- White to off-white Solid
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Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A617115
- Product name
- 2-Amino-4-pyrimidinecarbonitrile
- Packaging
- 25mg
- Price
- $90
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA154292
- Product name
- 2-Amino-4-cyanopyrimidine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA154292
- Product name
- 2-Amino-4-cyanopyrimidine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA154292
- Product name
- 2-Amino-4-cyanopyrimidine
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA154292
- Product name
- 2-Amino-4-cyanopyrimidine
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
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4-Pyrimidinecarbonitrile, 2-amino- (9CI) Chemical Properties,Usage,Production
Uses
2-Amino-4-pyrimidinecarbonitrile is a derivative of Pyrimidine (P997330), a heterocyclic organic molecule present in many pharmaceutical and naturally derived compounds.
Synthesis
557-21-1
815610-16-3
36314-98-4
General procedure for the synthesis of 2-amino-4-cyanopyrimidine from zinc cyanide and 2-amino-4-iodopyrimidine: a solution of N-methylpyrrolidone (NMP, 75 mL) containing 2-amino-4-iodopyrimidine (4.09 g, 18.5 mmol) was placed in a flask and purged with argon for 5 min to remove oxygen. Subsequently, zinc cyanide (2.28 g, 19.4 mmol) and tetrakis(triphenylphosphine)palladium(0) (1.71 g, 1.48 mmol) were added, and the reaction mixture was stirred at 80 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature, ethyl acetate (EtOAc, 200 mL) and 30% ammonia (NH4OH, 200 mL) were added, and stirring was continued for 1 hour. The organic and aqueous layers were separated and the aqueous layer was extracted with ethyl acetate (4 x 200 mL). All organic layers were combined and concentrated under reduced pressure. Ether (Et2O, 30 mL) was added to the concentrate, the precipitate was collected by filtration and washed with ether to afford 2-amino-4-cyanopyrimidine (1.66 g, 13.8 mmol, 75% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.51 (d, J = 4.7 Hz, 1H), 7.31 (br.s, 2H), 7.08 (d, J = 4.7 Hz, 1H). Mass spectrum (ESI, cation mode) m/z: 121.1 ([M+H]+).
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 80, p. 364 - 382
4-Pyrimidinecarbonitrile, 2-amino- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Pyrimidinecarbonitrile, 2-amino- (9CI) manufacturers
Dideu Industries Group Limited
- Product
- 4-Pyrimidinecarbonitrile, 2-amino- (9CI) 36314-98-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
Career Henan Chemical Co
- Product
- 4-Pyrimidinecarbonitrile, 2-amino- (9CI) 36314-98-4
- Price
- US $5.00/KG
- Min. Order
- 5KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-08-02